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Article Dans Une Revue Frontiers in Bioengineering and Biotechnology Année : 2023

Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear

Résumé

Introduction: Among the biopolymers used to make hydrogels, gelatin is very attractive due to its biocompatibility, biodegradability and versatile physicochemical properties. A proper and complete characterization of the mechanical behavior of these hydrogels is critical to evaluate the relevance of one formulation over another for a targeted application, and to optimise their processing route accordingly.Methods: In this work, we manufactured neat gelatin and gelatin covalently crosslinked with glutaraldehyde at various concentrations, yielding to hydrogels with tunable mechanical properties that we characterized under finite strain, cyclic tension, compression and shear loadings.Results and Discussion: The role of both the chemical formulation and the kinematical path on the mechanical performances of the gels is highlighted. As an opening towards biomedical applications, the properties of the gels are confronted to those of native soft tissues particularly complicated to restore, the human vocal folds. A specific cross-linked hydrogel is selected to mimic vocal-fold fibrous tissues.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-03935928 , version 2 (12-01-2023)
hal-03935928 , version 1 (01-09-2023)

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Hamid Yousefi-Mashouf, Lucie Bailly, Laurent Orgéas, Nathalie Henrich Bernardoni. Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear. Frontiers in Bioengineering and Biotechnology, 2023, 10, pp.1094197. ⟨10.3389/fbioe.2022.1094197⟩. ⟨hal-03935928v2⟩
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