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Article Dans Une Revue Organic Letters Année : 2023

Iron Catalyzed Dearomatization of Pyridines into Annelated Azepine Derivatives in a One-Step, Three-Component Reaction

Résumé

Commercially available Fe(TTP)Cl catalyzes three-component dearomative formal cycloaddition reactions between pyridines, diazo compounds, and coumalates. Diversely substituted annelated seven-membered N-heterocycles could be generated in less than 10 min in one step at room temperature. The reaction is compatible to gram scale. The extension to benzimidazoles in place of pyridines has been successfully demonstrated. The mechanism of this reaction has been carefully examined by computational studies that corroborate the observed regioselectivities.
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hal-03933345 , version 1 (21-04-2023)

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Alexander Mamontov, Liang Chang, Héloïse Dossmann, Benoît Bertrand, Luc Dechoux, et al.. Iron Catalyzed Dearomatization of Pyridines into Annelated Azepine Derivatives in a One-Step, Three-Component Reaction. Organic Letters, 2023, 25 (1), pp.256-260. ⟨10.1021/acs.orglett.2c04088⟩. ⟨hal-03933345⟩
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