Between 1593 and 1599, Queen Elizabeth I of England corresponded with the Ottoman Sultana Safiye (c. 1550-1606), favorite concubine of Sultan Murad III and mother of Sultan Mehmed III. Of this exchange, only the Sultana’s letters and mentions of the expensive and undeniably gendered gifts sent between London and Constantinople (such as English cosmetics, Ottoman female dresses and jewelry…) remain. And yet, these fragments give us insight into how two royal women of the early modern period, at a crossing between East and West, established a transcultural female circuit of exchange, not only to promote good diplomatic relationships but also to enable the transit of specifically female objects of status and power between the English court and the Ottoman harem. A close study of Elizabeth and Safiye’s correspondence, as well as the role of the Jewish kira (the Ottoman equivalent of a lady in waiting) Esperanza Malchi in relaying the correspondence between the royal harem and the English embassy, will help shed light on the often overlooked roles that female friendship and material culture played in foreign diplomacy, a subject that is only recently coming under attention in gender, global and material studies of the early modern period.