The Sars-Cov-2 pandemic seems to have surprised most political and health authorities by the speed that the virus spread and the need to control it through strict confinement measures, unprecedented in peacetime on a global scale. How can we understand the 'success' of the pathogen in geographical terms? This article aims to show that the pandemic was built from very specific characteristics of the urbanized world-system. Effectively, only the conditions of global urbanization could explain the geographical kinetic and exhaustiveness of the Covid-19 pandemic. The article also aims to understand how local and regional spatial differentiations of such phenomenon is established and, finally, proposes an interpretation of the pandemic, considering the anthropocene paradigm.