From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures - Archive ouverte HAL
Article Dans Une Revue Science Année : 2022

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures

Nicolò Caporale (1) , Michelle Leemans (2) , Lina Birgersson (3) , Pierre-Luc Germain (1) , Cristina Cheroni (1) , Gábor Borbély (4) , Elin Engdahl (5) , Christian Lindh (6) , Raul Bardini Bressan (7) , Francesca Cavallo (8) , Nadav Even Chorev (9) , Giuseppe Alessandro D’agostino (9) , Steven Pollard (7) , Marco Tullio Rigoli (9) , Erika Tenderini (9) , Alejandro Lopez Tobon (9) , Sebastiano Trattaro (9) , Flavia Troglio (9) , Matteo Zanella (9) , Åke Bergman (10) , Pauliina Damdimopoulou (11) , Maria Jönsson (5) , Wieland Kiess (12) , Efthymia Kitraki (13) , Hannu Kiviranta (14) , Eewa Nånberg (15) , Mattias Öberg (16) , Panu Rantakokko (17) , Christina Rudén (10) , Olle Söder (11) , Carl-Gustaf Bornehag (18) , Barbara Demeneix (2) , Jean-Baptiste Fini (2) , Chris Gennings (19) , Joëlle Rüegg (5) , Joachim Sturve (20) , Giuseppe Testa (9)
1 High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.
2 PhyMA - Physiologie moléculaire et adaptation
3 Department of Biological and Environmental Sciences [Gothenburg]
4 Swedish Toxicology Sciences Research Center (SWETOX)
5 Uppsala University
6 Skane University Hospital [Lund]
7 Edin. - University of Edinburgh
8 High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
9 High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
10 Stockholm University
11 Karolinska University Hospital [Stockholm]
12 Hospital for Children and Adolescents, Department of Women and Child Health, University Hospital, University of Leipzig, 04103 Leipzig, Germany
13 NKUA - National and Kapodistrian University of Athens
14 Department of Health Security, Finnish Institute for Health and Welfare (THL), Kuopio 70210, Finland
15 School of Health Sciences, Örebro University, SE-70182 Örebro, Sweden
16 Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden
17 Department of Health Security, Finnish Institute for Health and Welfare (THL), Kuopio 70210, Finland.
18 Karlstad University [Sweden]
19 MSSM - Icahn School of Medicine at Mount Sinai [New York]
20 Department of Biological and Environmental Sciences, University of Gothenburg, 41463 Gothenburg, Sweden
Nicolò Caporale
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.
Michelle Leemans
Physiologie moléculaire et adaptation
Lina Birgersson
  • Fonction : Auteur
Department of Biological and Environmental Sciences [Gothenburg]
Pierre-Luc Germain
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.
Cristina Cheroni
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.
Gábor Borbély
  • Fonction : Auteur
Swedish Toxicology Sciences Research Center (SWETOX)
Elin Engdahl
Uppsala University
Christian Lindh
Skane University Hospital [Lund]
Raul Bardini Bressan
University of Edinburgh
Francesca Cavallo
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Nadav Even Chorev
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Giuseppe Alessandro D’agostino
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Steven Pollard
University of Edinburgh
Marco Tullio Rigoli
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Erika Tenderini
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Alejandro Lopez Tobon
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Sebastiano Trattaro
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Flavia Troglio
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Matteo Zanella
  • Fonction : Auteur
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Åke Bergman
  • Fonction : Auteur
Stockholm University
Pauliina Damdimopoulou
Karolinska University Hospital [Stockholm]
Maria Jönsson
Uppsala University
Wieland Kiess
  • Fonction : Auteur
Hospital for Children and Adolescents, Department of Women and Child Health, University Hospital, University of Leipzig, 04103 Leipzig, Germany
Efthymia Kitraki
National and Kapodistrian University of Athens
Hannu Kiviranta
Department of Health Security, Finnish Institute for Health and Welfare (THL), Kuopio 70210, Finland
Eewa Nånberg
  • Fonction : Auteur
School of Health Sciences, Örebro University, SE-70182 Örebro, Sweden
Mattias Öberg
Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden
Panu Rantakokko
Department of Health Security, Finnish Institute for Health and Welfare (THL), Kuopio 70210, Finland.
Christina Rudén
Stockholm University
Olle Söder
Karolinska University Hospital [Stockholm]
Carl-Gustaf Bornehag
  • Fonction : Auteur
Karlstad University [Sweden]
Barbara Demeneix
Physiologie moléculaire et adaptation
Jean-Baptiste Fini
Physiologie moléculaire et adaptation
Chris Gennings
Icahn School of Medicine at Mount Sinai [New York]
Joëlle Rüegg
Uppsala University
Joachim Sturve
Department of Biological and Environmental Sciences, University of Gothenburg, 41463 Gothenburg, Sweden
Giuseppe Testa
High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy

Résumé

Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio , as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay.

Domaines

Sciences du Vivant [q-bio]

Jean-Baptiste FINI  : Connectez-vous pour contacter le contributeur

https://hal.science/hal-03919588

Soumis le : mardi 3 janvier 2023-01:04:15

Dernière modification le : lundi 30 septembre 2024-10:32:03

Consulter le texte intégral

Dates et versions

hal-03919588 , version 1 (03-01-2023)

Identifiants

Citer

Nicolò Caporale, Michelle Leemans, Lina Birgersson, Pierre-Luc Germain, Cristina Cheroni, et al.. From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures. Science, 2022, 375 (6582), ⟨10.1126/science.abe8244⟩. ⟨hal-03919588⟩

Exporter

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

MNHN CNRS PHYMA
60 Consultations
0 Téléchargements

Altmetric

Partager

More