Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): New insights on its role as a potential .OH inactivating ligand - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Inorganic Biochemistry Année : 2007

Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): New insights on its role as a potential .OH inactivating ligand

Résumé

The purpose of this study was to identify the low-molar-mass complexes formed between copper(II) and 3,5-diisopropylsalic acid (Dips) in physiological conditions. Copper(II)-Dips complex equilibria were determined using glass electrode potentiometry and their solution structures checked by UV-visible spectrophotometry. Because of the low solubility of Dips in water, the equilibria were investigated in different water/ethanol mixtures. Formation constants were extrapolated to 100% water and then compared with the values obtained for the other anti-inflammatory drugs previously studied. Given the prime role of histidine as the copper(II) ligand in blood plasma, copper(II)-histidine-Dips ternary equilibria were studied under similar experimental conditions. Computer simulations of copper(II) distribution relative to different biofluids, gastrointestinal (g.i.) fluid and blood plasma, show that like salicylic and anthranilic acids, Dips favors g.i. copper absorption, but cannot exert any significant influence on plasma copper distribution. Moreover, Dips can mobilize increasing fractions of copper(II) as the pH decreases. In conclusion, Dips seems to correspond to the notion of .OH-inactivating ligand (OIL) as determined for anthranilic acid.
Fichier principal
Vignette du fichier
Miche-CuHisDips-2007.pdf (737.79 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03897264 , version 1 (13-12-2022)

Identifiants

Citer

Veronique Brumas, Helene Miche, Marina Fiallo. Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): New insights on its role as a potential .OH inactivating ligand. Journal of Inorganic Biochemistry, 2007, 101 (4), pp.565-577. ⟨10.1016/j.jinorgbio.2006.11.017⟩. ⟨hal-03897264⟩
49 Consultations
26 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More