<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03896074</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T03:06:25+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The benefits of long read HiFi sequencing for metagenomic analysis</title>
            <author role="aut">
              <persName>
                <forename type="first">Adrien</forename>
                <surname>Castinel</surname>
              </persName>
              <email type="md5">9d5d8014d33615ac2d78ea8ea1d52545</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">adrien-castinel</idno>
              <idno type="idhal" notation="numeric">754699</idno>
              <idno type="halauthorid" notation="string">47598-754699</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7000-3408</idno>
              <affiliation ref="#struct-1002442"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Mainguy</surname>
              </persName>
              <email type="md5">2119a46962add43b9d49812bf545d04e</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">jeanmainguy</idno>
              <idno type="idhal" notation="numeric">1318475</idno>
              <idno type="halauthorid" notation="string">1959642-1318475</idno>
              <idno type="ORCID">https://orcid.org/0009-0006-9160-9744</idno>
              <affiliation ref="#struct-1002385"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Combes</surname>
              </persName>
              <email type="md5">3643440d6e58d71ae4549336941aa5a4</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">sylvie-combes</idno>
              <idno type="idhal" notation="numeric">184423</idno>
              <idno type="halauthorid" notation="string">14154-184423</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-9228-2018</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2945-4423</idno>
              <idno type="IDREF">https://www.idref.fr/185058019</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-9228-2018</idno>
              <affiliation ref="#struct-1002449"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Carole</forename>
                <surname>Iampietro</surname>
              </persName>
              <email type="md5">cffe938af0ad41cf637840c5047661e8</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">carole-iampietro</idno>
              <idno type="idhal" notation="numeric">751860</idno>
              <idno type="halauthorid" notation="string">50342-751860</idno>
              <idno type="IDREF">https://www.idref.fr/07510816X</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8148-4785</idno>
              <idno type="IDPINRA">ciampietro</idno>
              <affiliation ref="#struct-1002442"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christine</forename>
                <surname>Gaspin</surname>
              </persName>
              <email type="md5">0b828fd7f6e14de5e2488c58a7076ec4</email>
              <email type="domain">inra.fr</email>
              <idno type="idhal" notation="string">0000-0003-0304-5186</idno>
              <idno type="idhal" notation="numeric">735771</idno>
              <idno type="halauthorid" notation="string">36807-735771</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0304-5186</idno>
              <idno type="IDREF">https://www.idref.fr/081431481</idno>
              <affiliation ref="#struct-1002385"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Denis</forename>
                <surname>Milan</surname>
              </persName>
              <email type="md5">cbb60e075fdfd0716047f4ddaf2e064e</email>
              <email type="domain">inra.fr</email>
              <idno type="idhal" notation="string">denis-milan</idno>
              <idno type="idhal" notation="numeric">183743</idno>
              <idno type="halauthorid" notation="string">37033-183743</idno>
              <idno type="IDREF">https://www.idref.fr/068018940</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8062-5072</idno>
              <affiliation ref="#struct-1002442"/>
              <affiliation ref="#struct-1002449"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cécile</forename>
                <surname>Donnadieu</surname>
              </persName>
              <email type="md5">6372b69bece7e929e0d3db4629aaecd0</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">cdonnadieu</idno>
              <idno type="idhal" notation="numeric">804071</idno>
              <idno type="halauthorid" notation="string">695372-804071</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5164-3095</idno>
              <affiliation ref="#struct-1002442"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Hoede</surname>
              </persName>
              <email type="md5">7cd388d835ea3975656505c31167a5dc</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">claire-hoede</idno>
              <idno type="idhal" notation="numeric">735957</idno>
              <idno type="halauthorid" notation="string">8816-735957</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5054-7731</idno>
              <idno type="IDREF">https://www.idref.fr/150138237</idno>
              <affiliation ref="#struct-1002385"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Géraldine</forename>
                <surname>Pascal</surname>
              </persName>
              <email type="md5">95eecc2d00223a1fdd92c4dda5e42072</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">geraldine-pascal</idno>
              <idno type="idhal" notation="numeric">738247</idno>
              <idno type="halauthorid" notation="string">50479-738247</idno>
              <idno type="IDREF">https://www.idref.fr/09741218X</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5250-6594</idno>
              <affiliation ref="#struct-1002449"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Bouchez</surname>
              </persName>
              <email type="md5">5d10efd3a5952dcdcf87aab9c0f9b02e</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">obouchez</idno>
              <idno type="idhal" notation="numeric">1151095</idno>
              <idno type="halauthorid" notation="string">655433-1151095</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7255-0058</idno>
              <affiliation ref="#struct-1002442"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Adrien</forename>
                <surname>Castinel</surname>
              </persName>
              <email type="md5">9d5d8014d33615ac2d78ea8ea1d52545</email>
              <email type="domain">inrae.fr</email>
            </editor>
            <funder>FEDER (Programme Opérationnel FEDER-FSE_Midi-Pyrénées et Garonne 2014-2020).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-12-13 11:21:30</date>
              <date type="whenModified">2026-03-18 14:22:02</date>
              <date type="whenReleased">2022-12-16 14:49:11</date>
              <date type="whenProduced">2022-11-24</date>
              <date type="whenEndEmbargoed">2022-12-13</date>
              <ref type="file" target="https://hal.science/hal-03896074v1/document">
                <date notBefore="2022-12-13"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03896074v1/file/221212_Adrien_Castinel_metagenomic.pdf" id="file-3896074-3413681">
                <date notBefore="2022-12-13"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="869862">
                <persName>
                  <forename>Adrien</forename>
                  <surname>Castinel</surname>
                </persName>
                <email type="md5">9d5d8014d33615ac2d78ea8ea1d52545</email>
                <email type="domain">inrae.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03896074</idno>
            <idno type="halUri">https://hal.science/hal-03896074</idno>
            <idno type="halBibtex">castinel:hal-03896074</idno>
            <idno type="halRefHtml">&lt;i&gt;France génomique - VIIème Animation Wetlab et Bioinfo&lt;/i&gt;, Nov 2022, Strasbourg, France</idno>
            <idno type="halRef">France génomique - VIIème Animation Wetlab et Bioinfo, Nov 2022, Strasbourg, France</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3896074-3413681"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="ENSA-TOULOUSE">Ecole Nationale Supérieure Agronomique de Toulouse</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="GENETIQUE_ANIMALE">Département GA INRAE</idno>
            <idno type="stamp" n="GENPHYSE">Génétique Physiologie et Systèmes d'Elevage</idno>
            <idno type="stamp" n="INRAEOCCITANIETOULOUSE" corresp="INRAE">INRAE Occitanie Toulouse</idno>
            <idno type="stamp" n="PHASE">Physiologie animale et systèmes d’élevage</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="MATHNUM">Département MathNum</idno>
            <idno type="stamp" n="MIAT">Unité de Mathématiques et Informatique Appliquées de Toulouse</idno>
            <idno type="stamp" n="ENVT">École Nationale Vétérinaire de Toulouse </idno>
            <idno type="stamp" n="FRANCE-GENOMIQUE">France Génomique</idno>
            <idno type="stamp" n="GET-PLAGE" corresp="FRANCE-GENOMIQUE">Génome et Transcriptome - Plateforme Génomique</idno>
            <idno type="stamp" n="TEST-MATHNUM">Test MathNum</idno>
            <idno type="stamp" n="EIPURPAN">EIPURPAN</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="0">No</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The benefits of long read HiFi sequencing for metagenomic analysis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Adrien</forename>
                    <surname>Castinel</surname>
                  </persName>
                  <email type="md5">9d5d8014d33615ac2d78ea8ea1d52545</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">adrien-castinel</idno>
                  <idno type="idhal" notation="numeric">754699</idno>
                  <idno type="halauthorid" notation="string">47598-754699</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7000-3408</idno>
                  <affiliation ref="#struct-1002442"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Mainguy</surname>
                  </persName>
                  <email type="md5">2119a46962add43b9d49812bf545d04e</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">jeanmainguy</idno>
                  <idno type="idhal" notation="numeric">1318475</idno>
                  <idno type="halauthorid" notation="string">1959642-1318475</idno>
                  <idno type="ORCID">https://orcid.org/0009-0006-9160-9744</idno>
                  <affiliation ref="#struct-1002385"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Combes</surname>
                  </persName>
                  <email type="md5">3643440d6e58d71ae4549336941aa5a4</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">sylvie-combes</idno>
                  <idno type="idhal" notation="numeric">184423</idno>
                  <idno type="halauthorid" notation="string">14154-184423</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-9228-2018</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2945-4423</idno>
                  <idno type="IDREF">https://www.idref.fr/185058019</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-9228-2018</idno>
                  <affiliation ref="#struct-1002449"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Carole</forename>
                    <surname>Iampietro</surname>
                  </persName>
                  <email type="md5">cffe938af0ad41cf637840c5047661e8</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">carole-iampietro</idno>
                  <idno type="idhal" notation="numeric">751860</idno>
                  <idno type="halauthorid" notation="string">50342-751860</idno>
                  <idno type="IDREF">https://www.idref.fr/07510816X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8148-4785</idno>
                  <idno type="IDPINRA">ciampietro</idno>
                  <affiliation ref="#struct-1002442"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christine</forename>
                    <surname>Gaspin</surname>
                  </persName>
                  <email type="md5">0b828fd7f6e14de5e2488c58a7076ec4</email>
                  <email type="domain">inra.fr</email>
                  <idno type="idhal" notation="string">0000-0003-0304-5186</idno>
                  <idno type="idhal" notation="numeric">735771</idno>
                  <idno type="halauthorid" notation="string">36807-735771</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0304-5186</idno>
                  <idno type="IDREF">https://www.idref.fr/081431481</idno>
                  <affiliation ref="#struct-1002385"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Denis</forename>
                    <surname>Milan</surname>
                  </persName>
                  <email type="md5">cbb60e075fdfd0716047f4ddaf2e064e</email>
                  <email type="domain">inra.fr</email>
                  <idno type="idhal" notation="string">denis-milan</idno>
                  <idno type="idhal" notation="numeric">183743</idno>
                  <idno type="halauthorid" notation="string">37033-183743</idno>
                  <idno type="IDREF">https://www.idref.fr/068018940</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8062-5072</idno>
                  <affiliation ref="#struct-1002442"/>
                  <affiliation ref="#struct-1002449"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cécile</forename>
                    <surname>Donnadieu</surname>
                  </persName>
                  <email type="md5">6372b69bece7e929e0d3db4629aaecd0</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">cdonnadieu</idno>
                  <idno type="idhal" notation="numeric">804071</idno>
                  <idno type="halauthorid" notation="string">695372-804071</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5164-3095</idno>
                  <affiliation ref="#struct-1002442"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Hoede</surname>
                  </persName>
                  <email type="md5">7cd388d835ea3975656505c31167a5dc</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">claire-hoede</idno>
                  <idno type="idhal" notation="numeric">735957</idno>
                  <idno type="halauthorid" notation="string">8816-735957</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5054-7731</idno>
                  <idno type="IDREF">https://www.idref.fr/150138237</idno>
                  <affiliation ref="#struct-1002385"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Géraldine</forename>
                    <surname>Pascal</surname>
                  </persName>
                  <email type="md5">95eecc2d00223a1fdd92c4dda5e42072</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">geraldine-pascal</idno>
                  <idno type="idhal" notation="numeric">738247</idno>
                  <idno type="halauthorid" notation="string">50479-738247</idno>
                  <idno type="IDREF">https://www.idref.fr/09741218X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5250-6594</idno>
                  <affiliation ref="#struct-1002449"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Bouchez</surname>
                  </persName>
                  <email type="md5">5d10efd3a5952dcdcf87aab9c0f9b02e</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">obouchez</idno>
                  <idno type="idhal" notation="numeric">1151095</idno>
                  <idno type="halauthorid" notation="string">655433-1151095</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7255-0058</idno>
                  <affiliation ref="#struct-1002442"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>France génomique - VIIème Animation Wetlab et Bioinfo</title>
                  <date type="start">2022-11-24</date>
                  <date type="end">2022-11-25</date>
                  <settlement>Strasbourg</settlement>
                  <country key="FR">France</country>
                </meeting>
                <imprint/>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Whole genome analysis</term>
                <term xml:lang="en">Pacbio</term>
                <term xml:lang="en">Hifi</term>
                <term xml:lang="en">16S DNA sequencing</term>
                <term xml:lang="en">Metabarcoding analyses</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bbm.gtp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Today, the variable regions of 16S rRNA gene (V3-V4) is widely used to profile microbial communities, however the limited read lengths (460pb for the V3-V4 region) combined with the complexity of microbial samples makes it difficult to accurately identify bacterial strains and their abundance. The arrival PacBio Sequel II allow us to generate longer reads named “HiFi reads” using the circular consensus sequencing (CCS) mode, with an accuracy similar to the one observed on short reads. Therefore, we wanted to evaluate the taxonomic resolution using longer target region sequencing, such as, the full-length 16S (1.5kb) and 16S-23S genes (operon 4.5kb) and compared them to 16S RNA V3-V4 region. First, we have evaluated and implemented an extraction method in order to produce high size DNA fragment for long read sequencing while maintaining a good representativeness. Then, we conducted a comparative study of three PacBio protocols, the “Barcoded universal primers protocol” (BUP), the “Barcoded target specific primers protocol” (BTSP) and the “Barcoded overhang adapters protocol” (BOA) in order to perform CCS sequencing of the 16S, and 16S-23S genes on a microbial Community standard (mock) as well as pig faeces samples. Finally, we compared the taxonomic resolution between the 16S-23S, the 16S full length, and the 16sRNA V3V4.In parallel, we evaluated the benefits of PacBio long read technology as compared to Illumina short read technology for whole genome analysis. Microbial Community standard (mock) as well as pig faeces samples were sequenced on the Illumina NovaSeq and PacBio Sequel II sequencers. To analyse the data, we set up a new version of metagWGS (2.3) that allows the analysis of Illumina short-reads or PacBio HiFi long-reads  sequencing data and brings as a major new feature the binning of contigs. This work have been carried out within the framework of the SeqOccIn project (Sequencing Occitanie Innovation), supported by Get-PlaGe and Genotoul Bioinfo core facilities and financed by FEDER funds (Programme Opérationnel FEDER-FSE_Midi-Pyrénées et Garonne 2014-2020).</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1002442" status="OLD">
          <idno type="RNSR">201722711S</idno>
          <orgName>Génome et Transcriptome - Plateforme Génomique</orgName>
          <orgName type="acronym">GeT-PlaGe</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Campus INRA24 chemin de borde rouge - AuzevilleCS 5262731326 CASTANET-TOLOSAN Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://get.genotoul.fr/la-plateforme/get-plage/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-229658" type="direct"/>
            <relation active="#struct-1002361" type="indirect"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation name="UAR2039" active="#struct-441569" type="indirect"/>
            <relation active="#struct-577435" type="direct"/>
            <relation name="US 1426" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1002385" status="VALID">
          <idno type="RNSR">198717966P</idno>
          <orgName>Unité de Mathématiques et Informatique Appliquées de Toulouse</orgName>
          <orgName type="acronym">MIAT INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Chemin de Borde Rouge, 31320 Castanet Tolosan</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://carlit.toulouse.inra.fr/wikiz/index.php/Accueil</ref>
          </desc>
          <listRelation>
            <relation name="UR0875" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1002449" status="OLD">
          <idno type="RNSR">201421780T</idno>
          <orgName>Génétique Physiologie et Systèmes d'Elevage</orgName>
          <orgName type="acronym">GenPhySE</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>INRAE Auzeville - 24, chemin de Borde-Rouge -Auzeville Tolosane31326 Castanet Tolosan</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://genphyse.toulouse.inra.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-301264" type="direct"/>
            <relation active="#struct-460848" type="direct"/>
            <relation name="UMR1388" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-229658" status="OLD">
          <orgName>Plateforme Génome &amp; Transcriptome</orgName>
          <orgName type="acronym">GET</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Bio5 - INSA 135 Avenue de Rangueil 31077 Toulouse Cedex 04</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://get.genotoul.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1002361" type="direct"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation name="UAR2039" active="#struct-441569" type="indirect"/>
            <relation active="#struct-577435" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1002361" status="OLD">
          <idno type="RNSR">202424518A</idno>
          <orgName>Génopole Toulouse Midi-Pyrénées [Auzeville]</orgName>
          <orgName type="acronym">GENOTOUL</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Chemin de Borde-Rouge Auzeville</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation name="UAR2039" active="#struct-441569" type="direct"/>
            <relation active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300421" status="VALID">
          <idno type="ROR">https://ror.org/03m3gzv89</idno>
          <orgName>École nationale vétérinaire de Toulouse</orgName>
          <orgName type="acronym">ENVT</orgName>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles - 31076 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://envt.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-301264" status="VALID">
          <idno type="ISNI">0000 0001 2182 8729</idno>
          <idno type="ROR">https://ror.org/03d5w9863</idno>
          <orgName>École nationale supérieure agronomique de Toulouse</orgName>
          <orgName type="acronym">ENSAT, INP-ENSAT, AgroToulouse, INP-AgroToulouse</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ensat.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-460848" status="OLD">
          <idno type="ROR">https://ror.org/008bwpw24</idno>
          <orgName>Ecole d'Ingénieurs de Purpan</orgName>
          <orgName type="acronym">INP - PURPAN</orgName>
          <date type="start">2006-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.purpan.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>