A coupled model for the dynamics of gas exchanges in the human lung with Haldane and Bohr's effects - Archive ouverte HAL Access content directly
Journal Articles Journal of Theoretical Biology Year : 2023

A coupled model for the dynamics of gas exchanges in the human lung with Haldane and Bohr's effects

Abstract

We propose an integrated dynamical model for oxygen and carbon dioxide transfer from the lung into the blood, coupled with a lumped mechanical model for the ventilation process, for healthy patients as well as in pathological cases. In particular, we focus on the Bohr and Haldane effects, which induce a nonlinear coupling between the oxygen and the carbon dioxide. We also take into account the dead space volume, which requires a special attention in the pathological cases.
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Dates and versions

hal-03883301 , version 1 (03-12-2022)
hal-03883301 , version 2 (01-09-2023)

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Laurent Boudin, Céline Grandmont, Bérénice Grec, Sébastien Martin. A coupled model for the dynamics of gas exchanges in the human lung with Haldane and Bohr's effects. Journal of Theoretical Biology, 2023, 573, pp.111590. ⟨10.1016/j.jtbi.2023.111590⟩. ⟨hal-03883301v2⟩
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