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Article Dans Une Revue Cell Reports Medicine Année : 2022

Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques

Résumé

Given the time and resources invested in clinical trials, innovative prediction methods are needed to decrease late-stage failure in vaccine development. We identify combinations of early innate responses that predict neutralizing antibody (nAb) responses induced in HIV-Env SOSIP immunized cynomolgus macaques using various routes of vaccine injection and adjuvants. We analyze blood myeloid cells before and 24 h after each immunization by mass cytometry using a three-step clustering, and we discriminate unique vaccine signatures based on HLA-DR, CD39, CD86, CD11b, CD45, CD64, CD14, CD32, CD11c, CD123, CD4, CD16, and CADM1 surface expression. Various combinations of these markers characterize cell families positively associated with nAb production, whereas CADM1-expressing cells are negatively associated (p < 0.05). Our results demonstrate that monitoring immune signatures during early vaccine development could assist in identifying biomarkers that predict vaccine immunogenicity.
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Dates et versions

hal-03876903 , version 1 (29-11-2022)

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Matthieu van Tilbeurgh, Pauline Maisonnasse, Jean-Louis Palgen, Monica Tolazzi, Yoann Aldon, et al.. Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques. Cell Reports Medicine, 2022, 3 (10), pp.100751. ⟨10.1016/j.xcrm.2022.100751⟩. ⟨hal-03876903⟩
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