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Pré-Publication, Document De Travail Année : 2022

Widening the landscape of transcriptional regulation of algal photoprotection

Marius Arend
  • Fonction : Auteur
Yizhong Yuan
M. Águila Ruiz-Sola
Nooshin Omranian
Zoran Nikoloski
Dimitris Petroutsos
  • Fonction : Auteur
  • PersonId : 965585

Résumé

Abstract Availability of light and CO 2 , substrates of microalgae photosynthesis, is frequently far from optimal. Microalgae activate photoprotection under strong light, to prevent oxidative damage, and the CO 2 Concentrating Mechanism (CCM) under low CO 2 , to raise intracellular CO 2 levels. The two processes are interconnected; yet, the underlying transcriptional regulators remain largely unknown. By employing a large transcriptomics data compendium of Chlamydomonas reinhardtii’s responses to different light and carbon supply we reconstructed a consensus genome-scale gene regulatory network from complementary inference approaches and used it to elucidate the transcriptional regulation of photoprotection. We showed that the CCM regulator LCR1 also controls photoprotection, and that QER7, a Squamosa Binding Protein, suppresses photoprotection- and CCM-gene expression under the control of the blue light photoreceptor Phototropin. Along with demonstrating the existence of regulatory hubs that channel light- and CO 2 -mediated signals into a common response, our study provides a unique resource to dissect gene expression regulation in this microalga.

Dates et versions

hal-03876890 , version 1 (29-11-2022)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

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Marius Arend, Yizhong Yuan, M. Águila Ruiz-Sola, Nooshin Omranian, Zoran Nikoloski, et al.. Widening the landscape of transcriptional regulation of algal photoprotection. 2022. ⟨hal-03876890⟩
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