Mode of action of cyclic imine toxins: 20-methyl spirolide-G antagonizes rat neuronal α3β2 nicotinic acetylcholine receptor - Archive ouverte HAL Accéder directement au contenu
Proceedings/Recueil Des Communications Année : 2022

Mode of action of cyclic imine toxins: 20-methyl spirolide-G antagonizes rat neuronal α3β2 nicotinic acetylcholine receptor

Résumé

Cyclic imine toxins produced by marine dinoflagellate species move up fast the food chain through shellfish and constitute a potential threat for marine wildlife and public health because of their potent antagonistic activity against nicotinic acetylcholine receptors of muscle and neuronal types. Although not regulated, the lethality of 13-desmethyl spirolide-C does compare the lethality of saxitoxin in mouse bioassay. Besides, cyclic imine toxins are often found in shellfish destined for human consumption. Herein, the unveiling of the mode of action of cyclic imine toxins is reviewed. To illustrate the review, the electrophysiological characterization of the antagonistic capacity of 20-methyl spirolide-G on rat α3β2 nicotinic acetylcholine receptor is described.
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hal-03876880 , version 1 (29-11-2022)

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Amandine Gaudin, Rómulo Aráoz. Mode of action of cyclic imine toxins: 20-methyl spirolide-G antagonizes rat neuronal α3β2 nicotinic acetylcholine receptor. International Society for the Study of Harmful Algal Blooms., pp.205-211, 2022, 19th ICHA - Proceedings of the 19th International Conference on Harmful Algae, ⟨10.5281/zenodo.7035152⟩. ⟨hal-03876880⟩
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