Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion - Archive ouverte HAL
Article Dans Une Revue Genes and Development Année : 2008

Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion

Résumé

We describe here the role of histone deacetylase 3 (HDAC3) in sister chromatid cohesion and the deacetylation of histone H3 Lys 4 (H3K4) at the centromere. HDAC3 knockdown induced spindle assembly checkpoint activation and sister chromatid dissociation. The depletion of Polo-like kinase 1 (Plk1) or Aurora B restored cohesion in HDAC3-depleted cells. HDAC3 was also required for Shugoshin localization at centromeres. Finally, we show that HDAC3 depletion results in the acetylation of centromeric H3K4, correlated with a loss of dimethylation at the same position. These findings provide a functional link between sister chromatid cohesion and the mitotic “histone code”.

Dates et versions

hal-03875590 , version 1 (28-11-2022)

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Citer

Grégory Eot-Houllier, Géraldine Fulcrand, Yoshinori Watanabe, Laura Magnaghi-Jaulin, Christian Jaulin. Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion. Genes and Development, 2008, 22 (19), pp.2639-2644. ⟨10.1101/gad.484108⟩. ⟨hal-03875590⟩
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