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Journal Articles International Journal of Molecular Sciences Year : 2022

The IL-33/ST2 Pathway in Cerebral Malaria


Interleukin-33 (IL-33) is an immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. IL-33 is abundant within the brain and spinal cord tissues where it acts as a key cytokine to coordinate the exchange between the immune and central nervous system (CNS). In this review, we report the recent advances to our knowledge regarding the role of IL-33 and of its receptor ST2 in cerebral malaria, and in particular, we highlight the pivotal role that IL-33/ST2 signaling pathway could play in brain and cerebrospinal barriers permeability. IL-33 serum levels are significantly higher in children with severe Plasmodium falciparum malaria than children without complications or noninfected children. IL-33 levels are correlated with parasite load and strongly decrease with parasite clearance. We postulate that sequestration of infected erythrocytes or merozoites liberation from schizonts could amplify IL-33 production in endothelial cells, contributing either to malaria pathogenesis or recovery.
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hal-03874983 , version 1 (30-11-2022)





Corine Glineur, Inès Leleu, Sylviane Pied. The IL-33/ST2 Pathway in Cerebral Malaria. International Journal of Molecular Sciences, 2022, 23 (21), pp.13457. ⟨10.3390/ijms232113457⟩. ⟨hal-03874983⟩
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