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Journal Articles Science Advances Year : 2022

Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions

Stéphanie Jacquet
  • Function : Author
Michelle Culbertson
Chi Zhang
Adil El Filali
Clément de la Myre Mory
Jean-Baptiste Pons
  • Function : Author
Ondine Filippi-Codaccioni
  • Function : Author
M. Elise Lauterbur
Barthélémy Ngoubangoye
Jeanne Duhayer
  • Function : Author
Clément Verez
  • Function : Author
Chorong Park
Clara Dahoui
  • Function : Author
Clayton Carey
  • Function : Author
Greg Brennan
David Enard
Andrea Cimarelli
Stefan Rothenburg
Nels Elde
Dominique Pontier

Abstract

Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive selection and has undergone repeated genomic duplications in bats in contrast to all studied mammals that have a single copy of the gene. Functional testing of the relationship between PKR and poxvirus antagonists revealed how an evolutionary conflict with ancient pathogenic poxviruses has shaped a specific bat host-virus interface. We determined that duplicated PKRs of the Myotis species have undergone genetic diversification, allowing them to collectively escape from and enhance the control of DNA and RNA viruses. These findings suggest that viral-driven adaptations in PKR contribute to modern virus-bat interactions and may account for bat-specific immunity.

Dates and versions

hal-03872140 , version 1 (25-11-2022)

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Stéphanie Jacquet, Michelle Culbertson, Chi Zhang, Adil El Filali, Clément de la Myre Mory, et al.. Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions. Science Advances , 2022, 8 (47), ⟨10.1126/sciadv.add7540⟩. ⟨hal-03872140⟩
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