Background. This study aims to implement two interventions (CBT and hypnosis) for the management of cancer-related fatigue. Although CBT is known to be effective in treating cancer-related side effects, it requires specific training often reserved for psychologists. On the other hand, hypnosis has the advantage of being increasingly practiced by caregivers and is therefore less expensive, but it is more difficult to standardize. Implementing an intervention in a healthcare setting is complex and recruiting participants can be challenging. Thus, we aim to evaluate the feasibility of implementing this type of intervention. Methods and design. A prospective, single-center, randomized interventional feasibility study, using mixed methods (both quantitative and qualitative). 60 patients will be randomized and allocated to each intervention group (Hypnosis (n=30) and CBT (n=30)). Both programs will consist of 6 weekly sessions focusing on the fatigue management over a period of 6 weeks. Trained therapists will conduct the program combining 3 face-to-face sessions and 3 online sessions. The feasibility and experience of interventions will be evaluated by qualitative interviews. Quality of Life and daily fatigue will be self-assessment using an online application from the cancer center. Discussion. Inclusions are ongoing but the oral presentation could focus on the overview of the two interventions and in particular how the authors standardized the hypnosis sessions. Specific exercises are proposed to target the determinants of fatigue (eg. distress). The next step in this project is the opening of a multi-center RCT. An opportunity to discuss with clinicians and researchers interested in the interventions.