Article Dans Une Revue Nature Communications Année : 2018

Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

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Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoidresident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and nonlymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.

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hal-03863818 , version 1 (21-11-2022)

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Aurélie Durand, Alexandra Audemard-Verger, Vincent Guichard, Raphaël Mattiuz, Arnaud Delpoux, et al.. Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota. Nature Communications, 2018, 9 (1), pp.68. ⟨10.1038/s41467-017-02458-4⟩. ⟨hal-03863818⟩
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