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Article Dans Une Revue Nature Communications Année : 2022

Biological effects of the loss of homochirality in a multicellular organism

Agnes Banreti
Shayon Bhattacharya
Frank Wien
  • Fonction : Auteur
Koichi Matsuo
Cornelia Meinert
Uwe Meierhenrich
Bruno Hudry
Damien Thompson

Résumé

Abstract Homochirality is a fundamental feature of all known forms of life, maintaining biomolecules (amino-acids, proteins, sugars, nucleic acids) in one specific chiral form. While this condition is central to biology, the mechanisms by which the adverse accumulation of non- l- α-amino-acids in proteins lead to pathophysiological consequences remain poorly understood. To address how heterochirality build-up impacts organism’s health, we use chiral-selective in vivo assays to detect protein-bound non -l -α-amino acids (focusing on aspartate) and assess their functional significance in Drosophila . We find that altering the in vivo chiral balance creates a ‘heterochirality syndrome’ with impaired caspase activity, increased tumour formation, and premature death. Our work shows that preservation of homochirality is a key component of protein function that is essential to maintain homeostasis across the cell, tissue and organ level.
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hal-03862765 , version 1 (18-10-2023)

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Agnes Banreti, Shayon Bhattacharya, Frank Wien, Koichi Matsuo, Matthieu Réfrégiers, et al.. Biological effects of the loss of homochirality in a multicellular organism. Nature Communications, 2022, 13 (1), pp.7059. ⟨10.1038/s41467-022-34516-x⟩. ⟨hal-03862765⟩
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