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Article Dans Une Revue Nature Communications Année : 2022

Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march

Stefan Martin

Résumé

Abstract Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-03862150 , version 1 (20-04-2023)

Identifiants

Citer

Justine Segaud, Wenjin Yao, Pierre Marschall, François Daubeuf, Christine Lehalle, et al.. Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march. Nature Communications, 2022, 13 (1), pp.4703. ⟨10.1038/s41467-022-32196-1⟩. ⟨hal-03862150⟩
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