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Journal Articles Trends in Cancer Year : 2023

Challenges in glioblastoma research: focus on the tumor microenvironment

1 Inserm U1312 - BRIC - BoRdeaux Institute in onCology
2 IPMC - Institut de pharmacologie moléculaire et cellulaire
3 OSS - Oncogenesis, Stress, Signaling
4 CRLCC - CRLCC Eugène Marquis
5 NeuroPSI - Institut des Neurosciences Paris-Saclay
6 IGF - Institut de Génomique Fonctionnelle
7 CRCI2NA - Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers
8 DC2N - Différenciation et communication neuronale et neuroendocrine
9 IRIB - Institute for Research and Innovation in Biomedicine
10 NPS - Neuroscience Paris Seine
11 CHU Angers - Centre Hospitalier Universitaire d'Angers
12 4CS [Poitiers] - Canaux et Connexines dans les Cancers et Cellules Souches = Laboratory Channels and Connexins in Cancer and Cell Stemness [UMR 6041]
13 IBGC - Institut de biochimie et génétique cellulaires
14 LBP - Laboratoire de Bioimagerie et Pathologies
15 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
16 Centre Léon Bérard [Lyon]
17 ACPNP - Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]
18 PRISM - Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192
19 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
20 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
21 GHU Paris Psychiatrie et Neurosciences
22 CIRB - Centre interdisciplinaire de recherche en biologie
23 ICM - Institut du Cerveau = Paris Brain Institute
24 HCL - Hospices Civils de Lyon
25 Equipe CADIR (LNC - U1231)
26 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]
27 CRCT - Centre de Recherches en Cancérologie de Toulouse
28 Institut Claudius Regaud
29 CHU Charles Foix [AP-HP]
30 Signalisation, radiobiologie et cancer
31 INP - Institut de neurophysiopathologie
32 IBV - Institut de Biologie Valrose
Andreas Bikfalvi
  • Function : Author
  • PersonId : 967150
Luc Bauchet
Lucie Brisson
Hervé Chneiweiss
Monique Dontenwill
  • Function : Author
  • PersonId : 1079917
Jean-Philippe Hugnot
Marie-Pierre Junier
Thomas Mathivet
David Meyronet
Véronique Rousseau
  • Function : Author
  • PersonId : 867252
Giorgio Seano
Emeline Tabouret
Laurent Turchi
Thierry Virolle

Abstract

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has been recognized as an important player and therapeutic target in GBM. However, there is a need for a full and integrated understanding of the different cellular and molecular components involved in the GBM TME and their interactions for the development of more efficient therapies. In this review, we provide a comprehensive report of the GBM TME, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and therapy in France. We propose a holistic view of the subject by delineating the specific features of the GBM TME at the cellular, molecular, and therapeutic levels.
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hal-03860005 , version 1 (24-11-2022)

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Andreas Bikfalvi, Cristine Alves da Costa, Tony Avril, Jean-Vianney Barnier, Luc Bauchet, et al.. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends in Cancer, 2023, 9 (1), pp.9-27. ⟨10.1016/j.trecan.2022.09.005⟩. ⟨hal-03860005⟩
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