Microglia states and nomenclature: A field at its crossroads
Rosa C Paolicelli
(1)
,
Amanda Sierra
(2, 3, 4)
,
Beth Stevens
(5, 6, 7)
,
Marie-Ève Tremblay
(8, 9, 10, 11)
,
Adriano Aguzzi
(12)
,
Bahareh Ajami
(13)
,
Ido Amit
(14)
,
Etienne Audinat
(15)
,
Ingo Bechmann
(16)
,
Mariko Bennett
(17)
,
Frederick Bennett
(17, 18)
,
Alain Bessis
(19)
,
Knut Biber
(20)
,
Staci Bilbo
(21)
,
Mathew Blurton-Jones
(22)
,
Erik Boddeke
(23, 24)
,
Dora Brites
(25)
,
Bert Brône
(26)
,
Guy C Brown
(27)
,
Oleg Butovsky
(28)
,
Monica J Carson
(29)
,
Bernardo Castellano
(30)
,
Marco Colonna
(31)
,
Sally A Cowley
(32)
,
Colm Cunningham
(33)
,
Dimitrios Davalos
(34, 35)
,
Philip L de Jager
(36)
,
Bart de Strooper
(37, 38)
,
Ádám Dénes
(39)
,
Bart J L Eggen
(24, 23)
,
Ukpong Eyo
(40)
,
Elena Galea
(30, 41)
,
S. Garel
(42, 19)
,
Florent Ginhoux
(43, 44)
,
Christopher K Glass
(45)
,
Ozgun Gokce
(46)
,
Diego Gomez-Nicola
(47, 48)
,
Berta González
(30)
,
Siamon Gordon
(49, 32)
,
Manuel B Graeber
(50)
,
Andrew D Greenhalgh
(51)
,
Pierre Gressens
(52)
,
Melanie Greter
(12)
,
David H Gutmann
(53)
,
Christian Haass
(54, 55, 56)
,
Michael Heneka
(57)
,
Frank L Heppner
(58)
,
Soyon Hong
(38)
,
David A. Hume
(59)
,
Steffen Jung
(14)
,
Helmut Kettenmann
(60, 61)
,
Jonathan Kipnis
(62)
,
Ryuta Koyama
(63)
,
Greg Lemke
(64)
,
Marina Lynch
(33)
,
Ania Majewska
(65)
,
Marzia Malcangio
(66)
,
Tarja Malm
(67)
,
Renzo Mancuso
(68, 69)
,
Takahiro Masuda
(70)
,
Michela Matteoli
(71, 72)
,
Barry W Mccoll
(73)
,
Veronique E Miron
(74, 73)
,
Anna Victoria Molofsky
(75)
,
Michelle Monje
(5, 76)
,
Eva Mracsko
(77)
,
Agnès Nadjar
(78, 79)
,
Jonas J Neher
(55, 80)
,
Urte Neniskyte
(81)
,
Harald Neumann
(82, 83)
,
Mami Noda
(70, 84)
,
Bo Peng
(85, 86)
,
Francesca Peri
(12)
,
V. Hugh Perry
(38, 47)
,
Phillip G Popovich
(87)
,
Clare Pridans
(73)
,
Josef Priller
(88, 58, 55, 73, 38)
,
Marco Prinz
(89, 90)
,
Davide Ragozzino
(91, 92)
,
Richard M Ransohoff
(93)
,
Michael W Salter
(94, 95)
,
Anne Schaefer
(96, 97)
,
Dorothy Schafer
(98)
,
Michal Schwartz
(14)
,
Mikael Simons
(88, 55)
,
Cody J Smith
(99)
,
Wolfgang J Streit
(100)
,
Tuan Leng Tay
(101, 102)
,
Li-Huei Tsai
(7, 103)
,
Alexei Verkhratsky
(51, 3, 2)
,
Rommy von Bernhardi
(104)
,
Hiroaki Wake
(105)
,
Valérie Wittamer
(106, 107)
,
Susanne A Wolf
(58)
,
Long-Jun Wu
(108)
,
Tony Wyss-Coray
(76)
1
UNIL -
Université de Lausanne = University of Lausanne
2 Achucarro Basque Center for Neuroscience
3 UPV / EHU - Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]
4 Ikerbasque - Basque Foundation for Science
5 HHMI - Howard Hughes Medical Institute [Boston]
6 Boston Children's Hospital
7 BROAD INSTITUTE - Broad Institute of MIT and Harvard
8 CRCHUQ - Centre de recherche du CHU de Québec-Université Laval
9 McGill University = Université McGill [Montréal, Canada]
10 UVIC - University of Victoria [Canada]
11 University of British Columbia [Vancouver]
12 UZH - Universität Zürich [Zürich] = University of Zurich
13 OHSU - Oregon Health and Science University [Portland]
14 Weizmann Institute of Science [Rehovot, Israël]
15 IGF - Institut de Génomique Fonctionnelle
16 Leipzig University / Universität Leipzig
17 CHOP - Children’s Hospital of Philadelphia
18 Penn State - Pennsylvania State University
19 IBENS - Institut de biologie de l'ENS Paris
20 AbbVie Deutschland GmbH & Co KG
21 Duke University [Durham]
22 UC Irvine - University of California [Irvine]
23 UMCG - University Medical Center Groningen [Groningen]
24 University of Groningen [Groningen]
25 ULISBOA - Universidade de Lisboa = University of Lisbon = Université de Lisbonne
26 UHasselt - Hasselt University
27 Department of Biochemistry [Cambridge]
28 BWH - Brigham & Women’s Hospital [Boston]
29 UC Riverside - University of California [Riverside]
30 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
31 Washington University School of Medicine [Saint Louis, MO]
32 Sir William Dunn School of Pathology [Oxford]
33 Trinity College Dublin
34 Department of Neurosciences [Lerner Research Institute, Cleveland Clinic]
35 Case Western Reserve University [Cleveland]
36 CUIMC - Columbia University Irving Medical Center
37 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
38 UK DRI - UK Dementia Research Institute
39 KOKI - Institute of Experimental Medicine [Budapest]
40 University of Virginia
41 ICREA - Institució Catalana de Recerca i Estudis Avançats = Catalan Institution for Research and Advanced Studies
42 Collège de France - Chaire Neurobiologie et immunité
43 SIgN - Singapore Immunology Network
44 A*STAR - Agency for science, technology and research [Singapore]
45 UC San Diego - University of California [San Diego]
46 ISD - Institute for Stroke and Dementia Research
47 University of Southampton
48 Southampton General Hospital
49 Chang Gung University [Taïwan]
50 The University of Sydney
51 University of Manchester [Manchester]
52 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
53 Washington University School of Medicine in St. Louis
54 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
55 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
56 SyNergy - Munich Cluster for systems neurology [Munich]
57 LCSB - Luxembourg Centre For Systems Biomedicine
58 Charité - UniversitätsMedizin = Berlin University Medicine
59 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
60 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
61 SIAT - Shenzhen Institute of Advanced Technology [Shenzhen]
62 WUSTL - Washington University in Saint Louis
63 UTokyo - The University of Tokyo
64 The Salk Institute for Biological Studies
65 University of Rochester [USA]
66 King‘s College London
67 Faculty of Health Sciences [UEF, Kuopio, Finland]
68 VIB-UAntwerp - Center for Molecular Neurology
69 Universiteit Antwerpen = University of Antwerpen [Antwerpen]
70 Kyushu University
71 IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
72 CNR - Consiglio Nazionale delle Ricerche [Milano]
73 Edin. - University of Edinburgh
74 Queen's Medical Researche Institute
75 UC San Francisco - University of California [San Francisco]
76 Stanford University
77 Roche Innovation Center [Basel, Switzerland]
78 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
79 IUF - Institut universitaire de France
80 Hertie Institute for Clinical Brain Research [Tubingen]
81 Vilnius University [Vilnius]
82 UKB - Universitätsklinikum Bonn
83 Universität Bonn = University of Bonn
84 Xjtu - Xi'an Jiaotong University
85 Huashan Hospital [Shanghai, China]
86 Fudan University [Shanghai]
87 OSU - The Ohio State University [Columbus]
88 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
89 CIBSS - Centre for Integrative Biological Signalling Studies [Freiburg]
90 BIOSS - Centre for Biological Signaling Studies [Freiburg]
91 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
92 Fondazione Santa Lucia [IRCCS]
93 Third Rock Ventures
94 SickKids - The Hospital for sick children [Toronto]
95 University of Toronto
96 MSSM - Icahn School of Medicine at Mount Sinai [New York]
97 Max planck Institute for Biology of Ageing [Cologne]
98 UMASS - University of Massachusetts Medical School [Worcester]
99 UND - University of Notre Dame [Indiana]
100 UF - University of Florida [Gainesville]
101 Albert-Ludwigs-Universität Freiburg = University of Freiburg
102 BUSM - Boston University School of Medicine
103 MIT - Massachusetts Institute of Technology
104 USS - Universidad San Sebastian = San Sebastian University [Santiago, Chile]
105 Graduate School of Medical Sciences [Nagoya]
106 IRIBHM - Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire = Insitute of Interdisciplinary Research [Bruxelles, Belgique]
107 UNI - ULB Neuroscience Institute [Brussels]
108 Mayo Clinic [Rochester]
2 Achucarro Basque Center for Neuroscience
3 UPV / EHU - Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]
4 Ikerbasque - Basque Foundation for Science
5 HHMI - Howard Hughes Medical Institute [Boston]
6 Boston Children's Hospital
7 BROAD INSTITUTE - Broad Institute of MIT and Harvard
8 CRCHUQ - Centre de recherche du CHU de Québec-Université Laval
9 McGill University = Université McGill [Montréal, Canada]
10 UVIC - University of Victoria [Canada]
11 University of British Columbia [Vancouver]
12 UZH - Universität Zürich [Zürich] = University of Zurich
13 OHSU - Oregon Health and Science University [Portland]
14 Weizmann Institute of Science [Rehovot, Israël]
15 IGF - Institut de Génomique Fonctionnelle
16 Leipzig University / Universität Leipzig
17 CHOP - Children’s Hospital of Philadelphia
18 Penn State - Pennsylvania State University
19 IBENS - Institut de biologie de l'ENS Paris
20 AbbVie Deutschland GmbH & Co KG
21 Duke University [Durham]
22 UC Irvine - University of California [Irvine]
23 UMCG - University Medical Center Groningen [Groningen]
24 University of Groningen [Groningen]
25 ULISBOA - Universidade de Lisboa = University of Lisbon = Université de Lisbonne
26 UHasselt - Hasselt University
27 Department of Biochemistry [Cambridge]
28 BWH - Brigham & Women’s Hospital [Boston]
29 UC Riverside - University of California [Riverside]
30 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
31 Washington University School of Medicine [Saint Louis, MO]
32 Sir William Dunn School of Pathology [Oxford]
33 Trinity College Dublin
34 Department of Neurosciences [Lerner Research Institute, Cleveland Clinic]
35 Case Western Reserve University [Cleveland]
36 CUIMC - Columbia University Irving Medical Center
37 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
38 UK DRI - UK Dementia Research Institute
39 KOKI - Institute of Experimental Medicine [Budapest]
40 University of Virginia
41 ICREA - Institució Catalana de Recerca i Estudis Avançats = Catalan Institution for Research and Advanced Studies
42 Collège de France - Chaire Neurobiologie et immunité
43 SIgN - Singapore Immunology Network
44 A*STAR - Agency for science, technology and research [Singapore]
45 UC San Diego - University of California [San Diego]
46 ISD - Institute for Stroke and Dementia Research
47 University of Southampton
48 Southampton General Hospital
49 Chang Gung University [Taïwan]
50 The University of Sydney
51 University of Manchester [Manchester]
52 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
53 Washington University School of Medicine in St. Louis
54 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
55 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
56 SyNergy - Munich Cluster for systems neurology [Munich]
57 LCSB - Luxembourg Centre For Systems Biomedicine
58 Charité - UniversitätsMedizin = Berlin University Medicine
59 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
60 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
61 SIAT - Shenzhen Institute of Advanced Technology [Shenzhen]
62 WUSTL - Washington University in Saint Louis
63 UTokyo - The University of Tokyo
64 The Salk Institute for Biological Studies
65 University of Rochester [USA]
66 King‘s College London
67 Faculty of Health Sciences [UEF, Kuopio, Finland]
68 VIB-UAntwerp - Center for Molecular Neurology
69 Universiteit Antwerpen = University of Antwerpen [Antwerpen]
70 Kyushu University
71 IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
72 CNR - Consiglio Nazionale delle Ricerche [Milano]
73 Edin. - University of Edinburgh
74 Queen's Medical Researche Institute
75 UC San Francisco - University of California [San Francisco]
76 Stanford University
77 Roche Innovation Center [Basel, Switzerland]
78 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
79 IUF - Institut universitaire de France
80 Hertie Institute for Clinical Brain Research [Tubingen]
81 Vilnius University [Vilnius]
82 UKB - Universitätsklinikum Bonn
83 Universität Bonn = University of Bonn
84 Xjtu - Xi'an Jiaotong University
85 Huashan Hospital [Shanghai, China]
86 Fudan University [Shanghai]
87 OSU - The Ohio State University [Columbus]
88 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
89 CIBSS - Centre for Integrative Biological Signalling Studies [Freiburg]
90 BIOSS - Centre for Biological Signaling Studies [Freiburg]
91 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
92 Fondazione Santa Lucia [IRCCS]
93 Third Rock Ventures
94 SickKids - The Hospital for sick children [Toronto]
95 University of Toronto
96 MSSM - Icahn School of Medicine at Mount Sinai [New York]
97 Max planck Institute for Biology of Ageing [Cologne]
98 UMASS - University of Massachusetts Medical School [Worcester]
99 UND - University of Notre Dame [Indiana]
100 UF - University of Florida [Gainesville]
101 Albert-Ludwigs-Universität Freiburg = University of Freiburg
102 BUSM - Boston University School of Medicine
103 MIT - Massachusetts Institute of Technology
104 USS - Universidad San Sebastian = San Sebastian University [Santiago, Chile]
105 Graduate School of Medical Sciences [Nagoya]
106 IRIBHM - Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire = Insitute of Interdisciplinary Research [Bruxelles, Belgique]
107 UNI - ULB Neuroscience Institute [Brussels]
108 Mayo Clinic [Rochester]
Rosa C Paolicelli
- Fonction : Auteur
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Amanda Sierra
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Adriano Aguzzi
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Ido Amit
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Etienne Audinat
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Alain Bessis
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Oleg Butovsky
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Marco Colonna
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Bart de Strooper
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S. Garel
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Florent Ginhoux
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Siamon Gordon
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Pierre Gressens
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Melanie Greter
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Christian Haass
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Michael Heneka
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Michela Matteoli
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Michelle Monje
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Agnès Nadjar
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Clare Pridans
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Josef Priller
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Marco Prinz
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Davide Ragozzino
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Dorothy Schafer
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Michal Schwartz
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Alexei Verkhratsky
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Susanne A Wolf
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Résumé
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
Domaines
Neurobiologie
Fichier principal
Paolicelli et al Neuron 2022_Author version free PMC.pdf (1.85 Mo)
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| Origine | Publication financée par une institution |
|---|