Diving into the chemistry of sponge exo-metabolomes: contribution of brominated specialized metabolites
Résumé
Sponges produce structurally diverse specialized metabolites known for their biological/pharmacological potentials. In particular, the Mediterranean sponges Aplysina cavernicola and Agelas oroides produce brominated alkaloids with antimicrobial/anti-biofilm properties. A few targeted studies, performed on Caribbean species from the same genus, reported that the most abundant brominated alkaloid (e.g. aerothionin, oroidin) were detected in the seawater surrounding the sponges. Hence, such exo-metabolites (EM) could be collected from the seawater without destroying the sponge biomass.
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