Directed Dehydrogenative Copper‐Catalyzed C−H Thiolation in Pseudo‐Anomeric Position of Glycals using Thiol and Thiosugar Partners
Résumé
The synthesis of 1-thiotrehaloses and thioglycals by a directed copper-catalyzed dehydrogenative C−H thiolation of the pseudo-anomeric bond of glycals is described. The use of aminoquinoline-containing glycals as well as thiosugars or thiols as coupling partners led to the synthesis of a library of thioglycosides in moderate to good yields.
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