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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2022

Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints

Résumé

Significance Humoral immunity relies on the mutation and selection of B cells to better recognize pathogens. This affinity maturation process produces cells with diverse recognition capabilities. Examining optimal immune strategies that maximize the long-term immune coverage at a minimal metabolic cost, we show when the immune system should mount a de novo response rather than rely on existing memory cells. Our theory recapitulates known modes of the B cell response, predicts the empirical form of the distribution of clone sizes, and rationalizes as a trade-off between metabolic and immune costs the antigenic imprinting effects that limit the efficacy of vaccines (original antigenic sin). Our predictions provide a framework to interpret experimental results that could be used to inform vaccination strategies.

Dates et versions

hal-03854606 , version 1 (06-10-2021)
hal-03854606 , version 2 (15-11-2022)

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Victor Chardès, Massimo Vergassola, Aleksandra Walczak, Thierry Mora. Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (8), pp.e2113512119. ⟨10.1073/pnas.2113512119⟩. ⟨hal-03854606v2⟩
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