The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Data Paper) Science Advances Année : 2022

The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces

Résumé

Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous active matter processes and to vital morphogenetic and embryonic processes. Here, using interdisciplinary approaches, we study the dynamics of epithelial layers lining different cylindrical surfaces. We observe large-scale, persistent, and circumferential rotation in both concavely and convexly curved cylindrical tissues. While epithelia of inverse curvature show an orthogonal switch in actomyosin network orientation and opposite apicobasal polarities, their rotational movements emerge and vary similarly within a common curvature window. We further reveal that this persisting rotation requires stable cell-cell adhesion and Rac-1-dependent cell polarity. Using an active polar gel model, we unveil the different relationships of collective cell polarity and actin alignment with curvatures, which lead to coordinated rotational behavior despite the inverted curvature and cytoskeleton order.
Fichier principal
Vignette du fichier
sciadv.abn5406.pdf (12.41 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03854086 , version 1 (15-11-2022)

Licence

Paternité

Identifiants

Citer

Alexandros Glentis, Carles Blanch-Mercader, Lakshmi Balasubramaniam, Thuan Beng Saw, Joseph d’Alessandro, et al.. The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Science Advances , 2022, 16 (8(37)), pp.eabn5406. ⟨10.1126/sciadv.abn5406⟩. ⟨hal-03854086⟩
75 Consultations
36 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More