<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03853973</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T12:29:51+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias</title>
            <author role="aut">
              <persName>
                <forename type="first">Ming-Jun</forename>
                <surname>Shi</surname>
              </persName>
              <idno type="halauthorid">1717205-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jacqueline</forename>
                <surname>Fontugne</surname>
              </persName>
              <idno type="halauthorid">1707052-0</idno>
              <affiliation ref="#struct-580753"/>
              <affiliation ref="#struct-81173"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aura</forename>
                <surname>Moreno-Vega</surname>
              </persName>
              <idno type="halauthorid">1544831-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xiang-Yu</forename>
                <surname>Meng</surname>
              </persName>
              <idno type="halauthorid">1717208-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clarice</forename>
                <surname>Groeneveld</surname>
              </persName>
              <idno type="halauthorid">2347453-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florent</forename>
                <surname>Dufour</surname>
              </persName>
              <idno type="halauthorid">652841-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurélie</forename>
                <surname>Kamoun</surname>
              </persName>
              <idno type="halauthorid">1014447-0</idno>
              <affiliation ref="#struct-321644"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sia</forename>
                <surname>Viborg Lindskrog</surname>
              </persName>
              <idno type="halauthorid">2641702-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luc</forename>
                <surname>Cabel</surname>
              </persName>
              <idno type="halauthorid">1460188-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clémentine</forename>
                <surname>Krucker</surname>
              </persName>
              <idno type="halauthorid">1223173-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Rapinat</surname>
              </persName>
              <idno type="halauthorid">1698379-0</idno>
              <affiliation ref="#struct-301888"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Dunois-Larde</surname>
              </persName>
              <idno type="halauthorid">2641703-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">May-Linda</forename>
                <surname>Lepage</surname>
              </persName>
              <idno type="halauthorid">1054766-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elodie</forename>
                <surname>Chapeaublanc</surname>
              </persName>
              <email type="md5">f0dd0abca9af941627082467cd1bfe4c</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">echapeau</idno>
              <idno type="idhal" notation="numeric">1188545</idno>
              <idno type="halauthorid" notation="string">1223172-1188545</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9668-7753</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Levrel</surname>
              </persName>
              <idno type="halauthorid">2641704-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Victoria</forename>
                <surname>Dixon</surname>
              </persName>
              <idno type="halauthorid">2641696-0</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thierry</forename>
                <surname>Lebret</surname>
              </persName>
              <idno type="halauthorid">387158-0</idno>
              <affiliation ref="#struct-410109"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anna</forename>
                <surname>Almeida</surname>
              </persName>
              <idno type="halauthorid">1901388-0</idno>
              <affiliation ref="#struct-301888"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurélien</forename>
                <surname>de Reynies</surname>
              </persName>
              <idno type="halauthorid">364787-0</idno>
              <affiliation ref="#struct-321644"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Natacha</forename>
                <surname>Rochel</surname>
              </persName>
              <email type="md5">ab3cf19f82949b7aff218dfc351b11dd</email>
              <email type="domain">igbmc.fr</email>
              <idno type="idhal" notation="string">natacha-rochel</idno>
              <idno type="idhal" notation="numeric">740505</idno>
              <idno type="halauthorid" notation="string">5579-740505</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3573-5889</idno>
              <idno type="IDREF">https://www.idref.fr/183592468</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lars</forename>
                <surname>Dyrskjøt</surname>
              </persName>
              <idno type="halauthorid">1427001-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Allory</surname>
              </persName>
              <idno type="halauthorid">162404-0</idno>
              <affiliation ref="#struct-580753"/>
              <affiliation ref="#struct-81173"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Radvanyi</surname>
              </persName>
              <email type="md5">6d2b9450bb0f7913f40f036ca935d8f9</email>
              <email type="domain">curie.fr</email>
              <idno type="idhal" notation="numeric">756858</idno>
              <idno type="halauthorid" notation="string">159092-756858</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5696-6424</idno>
              <idno type="IDREF">https://www.idref.fr/033140774</idno>
              <idno type="VIAF">https://viaf.org/viaf/224755229</idno>
              <idno type="ISNI">http://isni.org/isni/0000000374938651</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Bernard-Pierrot</surname>
              </persName>
              <email type="md5">af3acd6740d6ff386f4a19767863c273</email>
              <email type="domain">curie.fr</email>
              <idno type="idhal" notation="string">isabelle-bernard-pierrot</idno>
              <idno type="idhal" notation="numeric">758638</idno>
              <idno type="halauthorid" notation="string">228552-758638</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8967-5092</idno>
              <idno type="IDREF">https://www.idref.fr/181817578</idno>
              <affiliation ref="#struct-580753"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Isabelle</forename>
                <surname>Bernard-Pierrot</surname>
              </persName>
              <email type="md5">af3acd6740d6ff386f4a19767863c273</email>
              <email type="domain">curie.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-16 09:55:04</date>
              <date type="whenModified">2025-10-10 03:14:11</date>
              <date type="whenReleased">2022-11-17 09:01:58</date>
              <date type="whenProduced">2022-10-21</date>
              <date type="whenEndEmbargoed">2022-11-16</date>
              <ref type="file" target="https://hal.science/hal-03853973v1/document">
                <date notBefore="2022-11-16"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-03853973v1/file/FGFR3-Shi2022-EU.pdf" id="file-3854867-3372880">
                <date notBefore="2022-11-16"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.1016/j.eururo.2022.09.030"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1105229">
                <persName>
                  <forename>Isabelle</forename>
                  <surname>Bernard-Pierrot</surname>
                </persName>
                <email type="md5">af3acd6740d6ff386f4a19767863c273</email>
                <email type="domain">curie.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03853973</idno>
            <idno type="halUri">https://hal.science/hal-03853973</idno>
            <idno type="halBibtex">shi:hal-03853973</idno>
            <idno type="halRefHtml">&lt;i&gt;European Urology&lt;/i&gt;, In press, 83 (1), pp.70 - 81. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.eururo.2022.09.030"&gt;&amp;#x27E8;10.1016/j.eururo.2022.09.030&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">European Urology, In press, 83 (1), pp.70 - 81. &amp;#x27E8;10.1016/j.eururo.2022.09.030&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3854867-3372880"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGBMC" corresp="INSERM">Institut Génétique de Biologie Moléculaire et Cellulaire</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="CURIE" corresp="INSERM">Institut Curie</idno>
            <idno type="stamp" n="UMR144" corresp="SORBONNE-UNIVERSITE">Biologie cellulaire et cancer</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="INSTITUT-CURIE-PSL" corresp="PSL">Institut Curie - PSL</idno>
            <idno type="stamp" n="UVSQ-UPSACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-UPSACLAY</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="SUPRA_PHYS_CHIMIE">Physico-Chimie</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Ming-Jun</forename>
                    <surname>Shi</surname>
                  </persName>
                  <idno type="halauthorid">1717205-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jacqueline</forename>
                    <surname>Fontugne</surname>
                  </persName>
                  <idno type="halauthorid">1707052-0</idno>
                  <affiliation ref="#struct-580753"/>
                  <affiliation ref="#struct-81173"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aura</forename>
                    <surname>Moreno-Vega</surname>
                  </persName>
                  <idno type="halauthorid">1544831-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xiang-Yu</forename>
                    <surname>Meng</surname>
                  </persName>
                  <idno type="halauthorid">1717208-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clarice</forename>
                    <surname>Groeneveld</surname>
                  </persName>
                  <idno type="halauthorid">2347453-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florent</forename>
                    <surname>Dufour</surname>
                  </persName>
                  <idno type="halauthorid">652841-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurélie</forename>
                    <surname>Kamoun</surname>
                  </persName>
                  <idno type="halauthorid">1014447-0</idno>
                  <affiliation ref="#struct-321644"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sia</forename>
                    <surname>Viborg Lindskrog</surname>
                  </persName>
                  <idno type="halauthorid">2641702-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luc</forename>
                    <surname>Cabel</surname>
                  </persName>
                  <idno type="halauthorid">1460188-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clémentine</forename>
                    <surname>Krucker</surname>
                  </persName>
                  <idno type="halauthorid">1223173-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Rapinat</surname>
                  </persName>
                  <idno type="halauthorid">1698379-0</idno>
                  <affiliation ref="#struct-301888"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Dunois-Larde</surname>
                  </persName>
                  <idno type="halauthorid">2641703-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">May-Linda</forename>
                    <surname>Lepage</surname>
                  </persName>
                  <idno type="halauthorid">1054766-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elodie</forename>
                    <surname>Chapeaublanc</surname>
                  </persName>
                  <email type="md5">f0dd0abca9af941627082467cd1bfe4c</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">echapeau</idno>
                  <idno type="idhal" notation="numeric">1188545</idno>
                  <idno type="halauthorid" notation="string">1223172-1188545</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9668-7753</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Levrel</surname>
                  </persName>
                  <idno type="halauthorid">2641704-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Victoria</forename>
                    <surname>Dixon</surname>
                  </persName>
                  <idno type="halauthorid">2641696-0</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thierry</forename>
                    <surname>Lebret</surname>
                  </persName>
                  <idno type="halauthorid">387158-0</idno>
                  <affiliation ref="#struct-410109"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anna</forename>
                    <surname>Almeida</surname>
                  </persName>
                  <idno type="halauthorid">1901388-0</idno>
                  <affiliation ref="#struct-301888"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurélien</forename>
                    <surname>de Reynies</surname>
                  </persName>
                  <idno type="halauthorid">364787-0</idno>
                  <affiliation ref="#struct-321644"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Natacha</forename>
                    <surname>Rochel</surname>
                  </persName>
                  <email type="md5">ab3cf19f82949b7aff218dfc351b11dd</email>
                  <email type="domain">igbmc.fr</email>
                  <idno type="idhal" notation="string">natacha-rochel</idno>
                  <idno type="idhal" notation="numeric">740505</idno>
                  <idno type="halauthorid" notation="string">5579-740505</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3573-5889</idno>
                  <idno type="IDREF">https://www.idref.fr/183592468</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lars</forename>
                    <surname>Dyrskjøt</surname>
                  </persName>
                  <idno type="halauthorid">1427001-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Allory</surname>
                  </persName>
                  <idno type="halauthorid">162404-0</idno>
                  <affiliation ref="#struct-580753"/>
                  <affiliation ref="#struct-81173"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Radvanyi</surname>
                  </persName>
                  <email type="md5">6d2b9450bb0f7913f40f036ca935d8f9</email>
                  <email type="domain">curie.fr</email>
                  <idno type="idhal" notation="numeric">756858</idno>
                  <idno type="halauthorid" notation="string">159092-756858</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5696-6424</idno>
                  <idno type="IDREF">https://www.idref.fr/033140774</idno>
                  <idno type="VIAF">https://viaf.org/viaf/224755229</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000374938651</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Bernard-Pierrot</surname>
                  </persName>
                  <email type="md5">af3acd6740d6ff386f4a19767863c273</email>
                  <email type="domain">curie.fr</email>
                  <idno type="idhal" notation="string">isabelle-bernard-pierrot</idno>
                  <idno type="idhal" notation="numeric">758638</idno>
                  <idno type="halauthorid" notation="string">228552-758638</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8967-5092</idno>
                  <idno type="IDREF">https://www.idref.fr/181817578</idno>
                  <affiliation ref="#struct-580753"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13147</idno>
                <idno type="issn">0302-2838</idno>
                <idno type="eissn">1421-993X</idno>
                <title level="j">European Urology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">83</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">70 - 81</biblScope>
                  <date type="datePub" subtype="inPress">2022-10-21</date>
                  <date type="dateEpub">2022-10-21</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.eururo.2022.09.030</idno>
              <idno type="pubmed">36273937</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Bladder cancer</term>
                <term xml:lang="en">receptor 3</term>
                <term xml:lang="en">Androgen receptor</term>
                <term xml:lang="en">Estrogen receptor</term>
                <term xml:lang="en">Sex bias</term>
                <term xml:lang="en">Mouse model</term>
                <term xml:lang="en">Luminal tumors</term>
                <term xml:lang="en">Tyrosine kinase receptor</term>
                <term xml:lang="en">Fibroblast growth factor</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.gtp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.un">Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: Bladder cancer (BCa) is more common in men and presents differences in molecular subtypes based on sex. Fibroblast growth factor receptor 3 (FGFR3) mutations are enriched in the luminal papillary muscle-invasive BCa (MIBC) and non-MIBC subtypes.Objective: To determine whether FGFR3 mutations initiate BCa and impact BCa male sex bias.Design, setting, and participants: We developed a transgenic mouse model expressing the most frequent FGFR3 mutation, FGFR3-S249C, in urothelial cells. Bladder tumorigenesis was monitored in transgenic mice, with and without carcinogen exposure. Mouse and human BCa transcriptomic data were compared.Intervention: Mutant FGFR3 overexpression in mouse urothelium and siRNA knockdown in cell lines, and N-butyl-N(4-hydroxybutyl)-nitrosamine (BBN) exposure.Outcome measurements and statistical analysis: Impact of transgene dosage on tumor frequency, synergy with BBN treatment, and FGFR3 pathway activation were analyzed. The sex-specific incidence of FGFR3-mutated tumors was evaluated in mice and humans. FGFR3 expression in FGFR3-S249C mouse urothelium and in various human epithelia was measured. Mutant FGFR3 regulation of androgen (AR) and estrogen (ESR1) receptor activity was evaluated, through target gene expression (regulon) and reporter assays.Results and limitations: FGFR3-S249C expression in mice induced low-grade papillary BCa resembling human luminal counterpart at histological, genomic, and transcriptomic levels, and promoted BBN-induced basal BCa formation. Mutant FGFR3 expression levels impacted tumor incidence in mice, and mutant FGFR3–driven human tumors were restricted to epithelia presenting high normal FGFR3 expression levels. BCa male sex bias, also found in our model, was even higher in human FGFR3-mutated tumors compared with wild-type tumors and was associated with higher AR and lower ESR1 regulon activity. Mutant FGFR3 expression inhibited both ESR1 and AR activity in mouse tumors and human cell lines, demonstrating causation only between FGFR3 activation and low ESR1 activity in tumors.Conclusions: Mutant FGFR3 initiates luminal papillary BCa formation and favors BCa male sex bias, potentially through FGFR3-dependent ESR1 downregulation. Patients with premalignant lesions or early-stage BCa could thus potentially benefit from FGFR3 targeting. FGFR3 expression level in epithelia could account for FGFR3-driven carcinoma tissue specificity.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-580753" status="VALID">
          <idno type="IdRef">252727819</idno>
          <idno type="RNSR">199511677U</idno>
          <idno type="ROR">04w11tv37</idno>
          <orgName>Biologie Cellulaire et Cancer</orgName>
          <date type="start">1995-01-01</date>
          <desc>
            <address>
              <addrLine>26 Rue d'Ulm 75248 PARIS CEDEX 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.curie.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301888" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR144" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-81173" status="VALID">
          <idno type="IdRef">03082057X</idno>
          <idno type="ISNI">0000 0001 2323 0229 </idno>
          <idno type="ROR">https://ror.org/03mkjjy25</idno>
          <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName>
          <orgName type="acronym">UVSQ</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uvsq.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-321644" status="VALID">
          <orgName>Ligue Nationale Contre le Cancer</orgName>
          <orgName type="acronym">LNCC</orgName>
          <date type="start">2022-04-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301888" status="VALID">
          <idno type="ISNI">0000 0004 0639 6384</idno>
          <idno type="ROR">https://ror.org/04t0gwh46</idno>
          <orgName>Institut Curie [Paris]</orgName>
          <desc>
            <address>
              <addrLine>26 rue d'Ulm - 75248 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://science.curie.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410109" status="VALID">
          <idno type="ROR">https://ror.org/058td2q88</idno>
          <orgName>Hôpital Foch [Suresnes]</orgName>
          <desc>
            <address>
              <addrLine>40 Rue Worth 92150 Suresnes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.hopital-foch.com/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-93800" status="VALID">
          <idno type="IdRef">155263749</idno>
          <idno type="ISNI">0000 0004 0638 2716</idno>
          <idno type="RNSR">200112491C</idno>
          <idno type="ROR">https://ror.org/0015ws592</idno>
          <idno type="Wikidata">Q3152004</idno>
          <orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName>
          <orgName type="acronym">IGBMC</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igbmc.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS964" active="#struct-199013" type="direct"/>
            <relation name="U1258" active="#struct-303623" type="direct"/>
            <relation name="UMR7104" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>