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Communication Dans Un Congrès Année : 2022

Neurotrophins promotes brain metastasis of triple negative breast cancer through Src kinase family activation

Francois Sipieter
Nicolas Borghi
Caroline Mysiorek

Résumé

With nearly 2.3 million cases diagnosed worldwide each year and an estimated 685 000 deaths by 2020, breast cancer is the leading cause of cancer-related death in women. Brain metastases cause severe cognitive complications that severely impair quality of life. In TN breast cancer, the prognosis for brain metastases is particularly poor with a median survival of no more than 6 months. It is therefore crucial to know the molecular actors that promote the metastatic dissemination of triple negative breast cancer to the brain but also to prevent the proliferation of brain micrometastases that can cause fatal recurrences. In order to recapitulate several final stages of brain metastasis, we used both human Blood- Brain-Barrier in vitro model, human organotypic 3D extracellular in vitro matrix, mice brain slices organotypic ex vivo culture and in vivo mice xenograft. These models are coupled with single cell, 3D and real time imaging techniques, including FRET biosensing. This unique experimental approach allows us to study the involvement of signaling pathways in these different biological processes. Using this innovative method, we have identified that inhibition neurotrophins receptor leads to a decrease in the activity of the underlying signaling pathways and consequently to a decrease in the ability of breast cancer cells to pass through the BBB, to grow and to colonize the brain parenchyma.
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Dates et versions

hal-03853963 , version 1 (15-11-2022)

Identifiants

  • HAL Id : hal-03853963 , version 1

Citer

Julien Cicero, Sarah Trouvilliez, Martine Palma, Gaetan Ternier, Laurine Decoster, et al.. Neurotrophins promotes brain metastasis of triple negative breast cancer through Src kinase family activation. 1st ONCOLille days 2022, Nov 2022, Lille, France. ⟨hal-03853963⟩
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