Pt nanoparticles with enhanced deaminase-like activity: example of oxidative deamination of 5-hydroxymethylfurfurylamine and glutamic acid. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemNanoMat Année : 2022

Pt nanoparticles with enhanced deaminase-like activity: example of oxidative deamination of 5-hydroxymethylfurfurylamine and glutamic acid.

Résumé

Oxidative deamination is part of the metabolic pathways of amino acid oxidase and glutamate dehydrogenase enzymes, and enables obtaining α-keto acid from amino compound with ammonia as a by-product. This work presents the utilization of Pt-based catalyst composed of small platinum nanoparticles supported on industrial silica support (Pt/SiO2). This nanozyme was tested in the oxidative deamination reaction of two amino compounds: 5-hydroxymethylfurfurylamine (HMFA) to 5-hydroxymethylfurfural (HMF) and glutamic acid (GA) to α-ketoglutaric acid (KGA). This paper outlines the use of Pt nanozymes with deaminase-like activity. We showed the ability of this nanozymes to be selective and active in liquid phase oxidative deamination of HMFA and glutamic acid in a 6 to 9 pH range at 60°C under atmospheric pressure. Pt/SiO2 nanozyme actually plays as a deaminase mimic with high HMFA conversion (60%) and cumulative yield to the corresponding desaminated keto compounds (67%).

Domaines

Catalyse
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Dates et versions

hal-03853675 , version 1 (15-11-2022)

Identifiants

Citer

Antoine Lancien, Egon Heuson, Franck Dumeignil, Ivaldo Itabaiana, Renato Froidevaux, et al.. Pt nanoparticles with enhanced deaminase-like activity: example of oxidative deamination of 5-hydroxymethylfurfurylamine and glutamic acid.. ChemNanoMat, 2022, 8 (5), pp.e202200062. ⟨10.1002/cnma.202200062⟩. ⟨hal-03853675⟩
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