Spatiotemporal reorganization of corticostriatal networks encodes motor skill learning - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2022

Spatiotemporal reorganization of corticostriatal networks encodes motor skill learning

Résumé

Motor skill learning requires the activity of the dorsal striatum, with a differential global implication of the dorsomedial and dorsolateral territories. We investigate here whether and how specific striatal neurons encode the acquisition and consolidation of a motor skill. Using ex vivo two-photon calcium imaging after rotarod training, we report that highly active (HA) striatal populations arise from distinct spatiotemporal reorganization in the dorsomedial (DMS) and dorsolateral (DLS) striatum networks and are correlated with learning performance. The DMS overall activity decreases in early training, with few and sparsely distributed HA cells, while the DLS shows a progressive and long-lasting formation of HA cell clusters. These reorganizations result from reinforcement of synaptic connections to the DMS and anatomical rearrangements to the DLS. Targeted silencing of DMS or DLS HA cells with the cFos-TRAP strategy strongly impairs individual performance. Our data reveal that discrete domains of striatal populations encode acquisition and long-lasting retention of a motor skill.
Fichier principal
Vignette du fichier
Badreddine et al., Cell Reports, 2022.pdf (4.91 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03852764 , version 1 (16-11-2022)

Identifiants

Citer

Nagham Badreddine, Gisela Zalcman, Florence Appaix, Guillaume Jean-Paul Claude Becq, Nicolas Tremblay, et al.. Spatiotemporal reorganization of corticostriatal networks encodes motor skill learning. Cell Reports, 2022, 39 (1), pp.110623. ⟨10.1016/j.celrep.2022.110623⟩. ⟨hal-03852764⟩
157 Consultations
35 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More