Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Data Paper) microPublication Biology Année : 2021

Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1

Suppression de him-14(it44ts) par une insertion transgénique exprimant GFP:COSA-1

Résumé

Meiotic crossover formation requires the activity of multiple pro-crossover factors, including the MutSγ complex and the cyclin-related protein COSA-1, that become concentrated together at the sites of crossover recombination intermediates. Here we show that a transgene insertion expressing GFP::COSA-1 can suppress the crossover deficit caused by a partial reduction in MutSγ function. Our data, combined with previous findings, support a model in which COSA-1 promotes crossover formation, at least in part, through positive regulation of MutSγ function.

Domaines

Génétique
Fichier principal
Vignette du fichier
micropub-biology-000430.pdf (811.4 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03852730 , version 1 (15-11-2022)

Licence

Paternité

Identifiants

Citer

Chloé Girard, Chantal C. Akerib, Anne M. Villeneuve. Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1. microPublication Biology, 2021, 2021, pp.000430. ⟨10.17912/micropub.biology.000430⟩. ⟨hal-03852730⟩
7 Consultations
10 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More