This chapter provides a non-exhaustive picture of the opportunities, experiences and transformations that have taken place over the last 10 years. Many of these have been, and increasingly will be, supported by the emergence of “new” technologies originally developed for the manufacturing sector. The chapter presents an example of an industrial cyber-physical systems (ICPS) prototype under construction. Following in the footsteps of the major groups, and in order to finally change the paradigm, the construction sector is stepping up its efforts and attempting to embark on the digital path. The best example of this is the digital mock-up and more specifically building information modeling. ICPS can be the source of important transformations in the construction sector. Several examples of the use of technologies and principles are detailed, according to the four functions of an ICPS, i.e. control, learn and interact, sense and distribute information, and digitalize.