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Journal Articles microPublication Biology Year : 2022

Left-right asymmetry in oxidative stress sensing neurons in C. elegans

Abstract

Perception of oxidative stress in nematodes involves specific neurons expressing antioxidant enzymes. Here, we carefully characterized GFP knock-in lines for C. elegans peroxiredoxin PRDX-2 and thioredoxin TRX-1, and uncovered that left and right I2, PHA and ASJ neurons reproducibly express an asymmetric level of each enzyme. We observed that high-expressing neurons are in most cases associated with a particular side, indicating a directional rather than stochastic type of asymmetry. We propose that the biological relevance of this left-right asymmetry is to fine-tune H 2 O 2 or light sensing, which remains to be investigated.
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Dates and versions

hal-03848989 , version 1 (11-11-2022)

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Sophie Quintin, Gilles Charvin. Left-right asymmetry in oxidative stress sensing neurons in C. elegans. microPublication Biology, 2022, ⟨10.17912/micropub.biology.000652⟩. ⟨hal-03848989⟩
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