<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03847263</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T20:15:54+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target</title>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Hottin</surname>
              </persName>
              <idno type="idhal" notation="numeric">1184714</idno>
              <idno type="halauthorid" notation="string">2046767-1184714</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4156-7631</idno>
              <affiliation ref="#struct-1051126"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Muriel</forename>
                <surname>Perron</surname>
              </persName>
              <email type="md5">044704d325e954e85b450d800ea64b9a</email>
              <email type="domain">cnrs.fr</email>
              <idno type="idhal" notation="string">muriel-perron</idno>
              <idno type="idhal" notation="numeric">741136</idno>
              <idno type="halauthorid" notation="string">4709-741136</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1558-8236</idno>
              <idno type="IDREF">https://www.idref.fr/08846847X</idno>
              <affiliation ref="#struct-1051126"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jérôme E.</forename>
                <surname>Roger</surname>
              </persName>
              <idno type="idhal" notation="numeric">823287</idno>
              <idno type="halauthorid" notation="string">1761105-823287</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5061-230X</idno>
              <idno type="IDREF">https://www.idref.fr/112933432</idno>
              <affiliation ref="#struct-1051126"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Alain</forename>
                <surname>PERIGNON</surname>
              </persName>
              <email type="md5">0915a8bc0b5a494fc86eb9724296445c</email>
              <email type="domain">cnrs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-10 15:01:52</date>
              <date type="whenModified">2024-08-06 10:25:39</date>
              <date type="whenReleased">2022-11-14 14:19:31</date>
              <date type="whenProduced">2022-09-16</date>
              <date type="whenEndEmbargoed">2022-11-10</date>
              <ref type="file" target="https://hal.science/hal-03847263v1/document">
                <date notBefore="2022-11-10"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-03847263v1/file/cells-11-02898-v2.pdf" id="file-3847302-3365174">
                <date notBefore="2022-11-10"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496697"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="108746">
                <persName>
                  <forename>Alain</forename>
                  <surname>PERIGNON</surname>
                </persName>
                <email type="md5">0915a8bc0b5a494fc86eb9724296445c</email>
                <email type="domain">cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03847263</idno>
            <idno type="halUri">https://hal.science/hal-03847263</idno>
            <idno type="halBibtex">hottin:hal-03847263</idno>
            <idno type="halRefHtml">&lt;i&gt;Cells&lt;/i&gt;, 2022, 11 (18), pp.2898. &lt;a target="_blank" href="https://dx.doi.org/10.3390/cells11182898"&gt;&amp;#x27E8;10.3390/cells11182898&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cells, 2022, 11 (18), pp.2898. &amp;#x27E8;10.3390/cells11182898&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3847302-3365174"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="NEURO-PSI">Institut des neurosciences Paris-Saclay</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Hottin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1184714</idno>
                  <idno type="halauthorid" notation="string">2046767-1184714</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4156-7631</idno>
                  <affiliation ref="#struct-1051126"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Muriel</forename>
                    <surname>Perron</surname>
                  </persName>
                  <email type="md5">044704d325e954e85b450d800ea64b9a</email>
                  <email type="domain">cnrs.fr</email>
                  <idno type="idhal" notation="string">muriel-perron</idno>
                  <idno type="idhal" notation="numeric">741136</idno>
                  <idno type="halauthorid" notation="string">4709-741136</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1558-8236</idno>
                  <idno type="IDREF">https://www.idref.fr/08846847X</idno>
                  <affiliation ref="#struct-1051126"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jérôme E.</forename>
                    <surname>Roger</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">823287</idno>
                  <idno type="halauthorid" notation="string">1761105-823287</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5061-230X</idno>
                  <idno type="IDREF">https://www.idref.fr/112933432</idno>
                  <affiliation ref="#struct-1051126"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">104588</idno>
                <idno type="issn">2073-4409</idno>
                <title level="j">Cells</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">18</biblScope>
                  <biblScope unit="pp">2898</biblScope>
                  <date type="datePub">2022-09-16</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/cells11182898</idno>
              <idno type="pubmed">36139472</idno>
              <idno type="pubmedcentral">PMC9496697</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">photoreceptors</term>
                <term xml:lang="en">GSK3</term>
                <term xml:lang="en">degeneration</term>
                <term xml:lang="en">ganglion cells</term>
                <term xml:lang="en">neuroprotection</term>
                <term xml:lang="en">signaling pathways</term>
                <term xml:lang="en">retina</term>
                <term xml:lang="en">retinal degenerative diseases</term>
              </keywords>
              <classCode scheme="mesh">Ependymoglial Cells</classCode>
              <classCode scheme="mesh">Glucose</classCode>
              <classCode scheme="mesh">Glycogen Synthase Kinase 3</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Retina</classCode>
              <classCode scheme="mesh">Retinal Degeneration</classCode>
              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halDomain" n="sdv.neu.pc">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior</classCode>
              <classCode scheme="halDomain" n="sdv.neu.sc">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Glycogen synthase kinase 3 (GSK3) is a key regulator of many cellular signaling processes and performs a wide range of biological functions in the nervous system. Due to its central role in numerous cellular processes involved in cell degeneration, a rising number of studies have highlighted the interest in developing therapeutics targeting GSK3 to treat neurodegenerative diseases. Although recent works strongly suggest that inhibiting GSK3 might also be a promising therapeutic approach for retinal degenerative diseases, its full potential is still under-evaluated. In this review, we summarize the literature on the role of GSK3 on the main cellular functions reported as deregulated during retinal degeneration, such as glucose homeostasis which is critical for photoreceptor survival, or oxidative stress, a major component of retinal degeneration. We also discuss the interest in targeting GSK3 for its beneficial effects on inflammation, for reducing neovascularization that occurs in some retinal dystrophies, or for cell-based therapy by enhancing Müller glia cell proliferation in diseased retina. Together, although GSK3 inhibitors hold promise as therapeutic agents, we highlight the complexity of targeting such a multitasked kinase and the need to increase our knowledge of the impact of reducing GSK3 activity on these multiple cellular pathways and biological processes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1051126" status="VALID">
          <orgName>Institut des Neurosciences Paris-Saclay</orgName>
          <orgName type="acronym">NeuroPSI</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Centre National de la Recherche Scientifique, Unité Mixte de Recherche-9197 Université Paris-SaclayCampus CEA Saclay, Bât. 151151 route de la Rotonde91400 Saclay</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://neuropsi.cnrs.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-419361" type="direct"/>
            <relation name="UMR9197" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>