Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Science Advances Année : 2019

Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns

Massiré Traoré
Z.-D. Deng

Résumé

Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic stimulation at low-intensity (LI-rTMS) induces axon outgrowth and synaptogenesis to repair a neural circuit. This repair depends on stimulation pattern, with complex biomimetic patterns being particularly effective, and the presence of cryptochrome, a putative magnetoreceptor. Only repair-promoting LI-rTMS patterns up-regulated genes involved in neuronal repair; almost 40% of were cryptochrome targets. Our data open a new framework to understand the mechanisms underlying structural neuroplasticity induced by electromagnetic stimulation. Rather than neuronal activation by induced electric currents, we propose that weak magnetic fields act through cryptochrome to activate cellular signaling cascades. This information opens new routes to optimize electromagnetic stimulation and develop effective treatments for different neurological diseases.
Fichier principal
Vignette du fichier
aav9847.pdf (2.41 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03843646 , version 1 (08-11-2022)

Identifiants

Citer

T. Dufor, S. Grehl, A. Tang, M. Doulazmi, Massiré Traoré, et al.. Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns. Science Advances , 2019, 5 (10), pp.eaav9847. ⟨10.1126/sciadv.aav9847⟩. ⟨hal-03843646⟩
15 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More