L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects - Archive ouverte HAL Access content directly
Journal Articles Cells Year : 2022

L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects

La L-Thyroxine améliore la compensation vestibulaire dans un modèle de rat de vestibulopathie périphérique aiguë : Aspects cellulaires et comportementaux

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Guillaume Rastoldo
  • Function : Author
Emna Marouane
Nada El-Mahmoudi
  • Function : Author
David Péricat
  • Function : Author
Isabelle Watabe
Agnes Lapotre
  • Function : Author
Alain Tonetto
  • Function : Author
Alejandra López-Juárez
  • Function : Author
Abdessadek El-Ahmadi
  • Function : Author
Philippe Caron
  • Function : Author
Marie-José Esteve Fraysse
  • Function : Author
Andreas Zwergal
  • Function : Author
Brahim Tighilet

Abstract

Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modulated glial reaction by decreasing both microglia and oligodendrocytes in the deafferented VN three days after UVN and increased cell proliferation. Survival of newly generated cells in the deafferented vestibular nuclei was not affected, but microglial rather than neuronal differentiation was favored by L-T4 treatment.

Dates and versions

hal-03843246 , version 1 (08-11-2022)

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Guillaume Rastoldo, Emna Marouane, Nada El-Mahmoudi, David Péricat, Isabelle Watabe, et al.. L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects. Cells, 2022, 11 (4), pp.684. ⟨10.3390/cells11040684⟩. ⟨hal-03843246⟩
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