Molecular basis of antifungal drug resistance in yeasts - Archive ouverte HAL
Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2017

Molecular basis of antifungal drug resistance in yeasts

Résumé

Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire re- sistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifun- gal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key mo- lecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal sus- ceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.
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Dates et versions

hal-03842639 , version 1 (07-11-2022)

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Florent Morio, Rasmus Hare Jensen, Patrice Le Pape, Maiken Cavling Arendrup. Molecular basis of antifungal drug resistance in yeasts. International Journal of Antimicrobial Agents, 2017, 50 (5), pp.599-606. ⟨10.1016/j.ijantimicag.2017.05.012⟩. ⟨hal-03842639⟩
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