<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03841174</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T18:00:59+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model</title>
            <author role="aut">
              <persName>
                <forename type="first">Dounia</forename>
                <surname>Ben Amar</surname>
              </persName>
              <idno type="halauthorid">2632747-0</idno>
              <affiliation ref="#struct-1096342"/>
              <affiliation ref="#struct-476908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karine</forename>
                <surname>Thoinet</surname>
              </persName>
              <idno type="halauthorid">421039-0</idno>
              <affiliation ref="#struct-1096342"/>
              <affiliation ref="#struct-476908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <surname>Villalard</surname>
              </persName>
              <idno type="idhal" notation="numeric">1182619</idno>
              <idno type="halauthorid" notation="string">2632753-1182619</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4187-6389</idno>
              <affiliation ref="#struct-1096342"/>
              <affiliation ref="#struct-476908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Imbaud</surname>
              </persName>
              <idno type="halauthorid">1790095-0</idno>
              <affiliation ref="#struct-1096342"/>
              <affiliation ref="#struct-476908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clélia</forename>
                <surname>Costechareyre</surname>
              </persName>
              <idno type="halauthorid">1590291-0</idno>
              <affiliation ref="#struct-1079399"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Loraine</forename>
                <surname>Jarrosson</surname>
              </persName>
              <idno type="halauthorid">1710786-0</idno>
              <affiliation ref="#struct-1079399"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florie</forename>
                <surname>Reynaud</surname>
              </persName>
              <idno type="halauthorid">429916-0</idno>
              <affiliation ref="#struct-476908"/>
              <affiliation ref="#struct-1096342"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julia</forename>
                <surname>Novion Ducassou</surname>
              </persName>
              <idno type="halauthorid">2046621-0</idno>
              <affiliation ref="#struct-1061087"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yohann</forename>
                <surname>Couté</surname>
              </persName>
              <email type="md5">7f000b56440ba769831529a5c64eb00e</email>
              <email type="domain">cea.fr</email>
              <idno type="idhal" notation="string">yohann-coute</idno>
              <idno type="idhal" notation="numeric">173505</idno>
              <idno type="halauthorid" notation="string">2544719-173505</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-2695-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3896-6196</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=pUQIR6wAAAAJ&amp;hl=fr&amp;oi=ao</idno>
              <idno type="IDREF">https://www.idref.fr/07617347X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-2695-2015</idno>
              <affiliation ref="#struct-1061087"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Brunet</surname>
              </persName>
              <idno type="halauthorid">178861-0</idno>
              <affiliation ref="#struct-106195"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Combaret</surname>
              </persName>
              <idno type="halauthorid">213761-0</idno>
              <affiliation ref="#struct-20549"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadège</forename>
                <surname>Corradini</surname>
              </persName>
              <email type="md5">b05a65c85a668be42ab2adbc3d6df478</email>
              <email type="domain">lyon.unicancer.fr</email>
              <idno type="idhal" notation="numeric">817426</idno>
              <idno type="halauthorid" notation="string">558636-817426</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1942-1222</idno>
              <affiliation ref="#struct-20549"/>
              <affiliation ref="#struct-348446"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Delloye-Bourgeois</surname>
              </persName>
              <email type="md5">e5d10e1a65051736b082de5425f5d5da</email>
              <email type="domain">univ-lyon1.fr</email>
              <idno type="idhal" notation="string">celine-delloye-bourgeois</idno>
              <idno type="idhal" notation="numeric">1182617</idno>
              <idno type="halauthorid" notation="string">406609-1182617</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-8988-2017</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7162-0034</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-8988-2017</idno>
              <affiliation ref="#struct-476908"/>
              <affiliation ref="#struct-1096342"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Castellani</surname>
              </persName>
              <email type="md5">afae609fb7360875a201c7864769733d</email>
              <email type="domain">univ-lyon1.fr</email>
              <idno type="idhal" notation="string">valerie-castellani</idno>
              <idno type="idhal" notation="numeric">932405</idno>
              <idno type="halauthorid" notation="string">232206-932405</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-3100-2017</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-3100-2017</idno>
              <affiliation ref="#struct-476908"/>
              <affiliation ref="#struct-1096342"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Céline</forename>
                <surname>Delloye-Bourgeois</surname>
              </persName>
              <email type="md5">2ab83c67a0937b640d3f01d05464cf5e</email>
              <email type="domain">lyon.unicancer.fr</email>
            </editor>
            <funder ref="#projanr-50259"/>
            <funder ref="#projanr-49741"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-16 14:17:10</date>
              <date type="whenModified">2026-04-21 15:44:54</date>
              <date type="whenReleased">2022-11-21 11:50:08</date>
              <date type="whenProduced">2022-12</date>
              <date type="whenEndEmbargoed">2022-11-16</date>
              <ref type="file" target="https://hal.science/hal-03841174v1/document">
                <date notBefore="2022-11-16"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-03841174v1/file/BenAmar_NatComms_2022.pdf" id="file-3855678-3371789">
                <date notBefore="2022-11-16"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091272"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="637500">
                <persName>
                  <forename>Céline</forename>
                  <surname>Delloye-Bourgeois</surname>
                </persName>
                <email type="md5">2ab83c67a0937b640d3f01d05464cf5e</email>
                <email type="domain">lyon.unicancer.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03841174</idno>
            <idno type="halUri">https://hal.science/hal-03841174</idno>
            <idno type="halBibtex">benamar:hal-03841174</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature Communications&lt;/i&gt;, 2022, 13 (1), pp.2549. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41467-022-30237-3"&gt;&amp;#x27E8;10.1038/s41467-022-30237-3&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature Communications, 2022, 13 (1), pp.2549. &amp;#x27E8;10.1038/s41467-022-30237-3&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3855678-3371789"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="ENS-PARIS">Ecole Normale Supérieure de Paris</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="CRCL" corresp="UNIV-LYON1">Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard)</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="ENS-PSL" corresp="PSL">École normale supérieure - PSL</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="CRCL-EQUIPE-C-DELLOYE-BOURGEOIS" corresp="CRCL">CRCL-Neuroscience du cancer et métastases des tumeurs pédiatriques agressives </idno>
            <idno type="stamp" n="MELIS">Mécanismes en sciences intégratives du vivant</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Dounia</forename>
                    <surname>Ben Amar</surname>
                  </persName>
                  <idno type="halauthorid">2632747-0</idno>
                  <affiliation ref="#struct-1096342"/>
                  <affiliation ref="#struct-476908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karine</forename>
                    <surname>Thoinet</surname>
                  </persName>
                  <idno type="halauthorid">421039-0</idno>
                  <affiliation ref="#struct-1096342"/>
                  <affiliation ref="#struct-476908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <surname>Villalard</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1182619</idno>
                  <idno type="halauthorid" notation="string">2632753-1182619</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4187-6389</idno>
                  <affiliation ref="#struct-1096342"/>
                  <affiliation ref="#struct-476908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Imbaud</surname>
                  </persName>
                  <idno type="halauthorid">1790095-0</idno>
                  <affiliation ref="#struct-1096342"/>
                  <affiliation ref="#struct-476908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clélia</forename>
                    <surname>Costechareyre</surname>
                  </persName>
                  <idno type="halauthorid">1590291-0</idno>
                  <affiliation ref="#struct-1079399"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Loraine</forename>
                    <surname>Jarrosson</surname>
                  </persName>
                  <idno type="halauthorid">1710786-0</idno>
                  <affiliation ref="#struct-1079399"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florie</forename>
                    <surname>Reynaud</surname>
                  </persName>
                  <idno type="halauthorid">429916-0</idno>
                  <affiliation ref="#struct-476908"/>
                  <affiliation ref="#struct-1096342"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julia</forename>
                    <surname>Novion Ducassou</surname>
                  </persName>
                  <idno type="halauthorid">2046621-0</idno>
                  <affiliation ref="#struct-1061087"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yohann</forename>
                    <surname>Couté</surname>
                  </persName>
                  <email type="md5">7f000b56440ba769831529a5c64eb00e</email>
                  <email type="domain">cea.fr</email>
                  <idno type="idhal" notation="string">yohann-coute</idno>
                  <idno type="idhal" notation="numeric">173505</idno>
                  <idno type="halauthorid" notation="string">2544719-173505</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-2695-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3896-6196</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=pUQIR6wAAAAJ&amp;hl=fr&amp;oi=ao</idno>
                  <idno type="IDREF">https://www.idref.fr/07617347X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-2695-2015</idno>
                  <affiliation ref="#struct-1061087"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Brunet</surname>
                  </persName>
                  <idno type="halauthorid">178861-0</idno>
                  <affiliation ref="#struct-106195"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Combaret</surname>
                  </persName>
                  <idno type="halauthorid">213761-0</idno>
                  <affiliation ref="#struct-20549"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadège</forename>
                    <surname>Corradini</surname>
                  </persName>
                  <email type="md5">b05a65c85a668be42ab2adbc3d6df478</email>
                  <email type="domain">lyon.unicancer.fr</email>
                  <idno type="idhal" notation="numeric">817426</idno>
                  <idno type="halauthorid" notation="string">558636-817426</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1942-1222</idno>
                  <affiliation ref="#struct-20549"/>
                  <affiliation ref="#struct-348446"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Delloye-Bourgeois</surname>
                  </persName>
                  <email type="md5">e5d10e1a65051736b082de5425f5d5da</email>
                  <email type="domain">univ-lyon1.fr</email>
                  <idno type="idhal" notation="string">celine-delloye-bourgeois</idno>
                  <idno type="idhal" notation="numeric">1182617</idno>
                  <idno type="halauthorid" notation="string">406609-1182617</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-8988-2017</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7162-0034</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-8988-2017</idno>
                  <affiliation ref="#struct-476908"/>
                  <affiliation ref="#struct-1096342"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Castellani</surname>
                  </persName>
                  <email type="md5">afae609fb7360875a201c7864769733d</email>
                  <email type="domain">univ-lyon1.fr</email>
                  <idno type="idhal" notation="string">valerie-castellani</idno>
                  <idno type="idhal" notation="numeric">932405</idno>
                  <idno type="halauthorid" notation="string">232206-932405</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-3100-2017</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-3100-2017</idno>
                  <affiliation ref="#struct-476908"/>
                  <affiliation ref="#struct-1096342"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">67823</idno>
                <idno type="issn">2041-1723</idno>
                <idno type="eissn">2041-1723</idno>
                <title level="j">Nature Communications</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">13</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">2549</biblScope>
                  <date type="datePub">2022-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41467-022-30237-3</idno>
              <idno type="pubmed">35538114</idno>
              <idno type="pubmedcentral">PMC9091272</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Abstract Embryonic malignant transformation is concomitant to organogenesis, often affecting multipotent and migratory progenitors. While lineage relationships between malignant cells and their physiological counterparts are extensively investigated, the contribution of exogenous embryonic signals is not fully known. Neuroblastoma (NB) is a childhood malignancy of the peripheral nervous system arising from the embryonic trunk neural crest (NC) and characterized by heterogeneous and interconvertible tumor cell identities. Here, using experimental models mimicking the embryonic context coupled to proteomic and transcriptomic analyses, we show that signals released by embryonic sympathetic ganglia, including Olfactomedin-1, induce NB cells to shift from a noradrenergic to mesenchymal identity, and to activate a gene program promoting NB metastatic onset and dissemination. From this gene program, we extract a core signature specifically shared by metastatic cancers with NC origin. This reveals non-cell autonomous embryonic contributions regulating the plasticity of NB identities and setting pro-dissemination gene programs common to NC-derived cancers.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1096342" status="VALID">
          <idno type="IdRef">271157615</idno>
          <idno type="RNSR">202224172H</idno>
          <idno type="ROR">01138xk88</idno>
          <orgName>Mécanismes en sciences intégratives du vivant</orgName>
          <orgName type="acronym">MeLiS</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine et de Pharmacie - 3ème étage8 avenue Rockefeller69008 LYON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://inmg.fr/melis/fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="U1314" active="#struct-303623" type="direct"/>
            <relation name="UMR5284" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-476908" status="OLD">
          <idno type="IdRef">197570461</idno>
          <orgName>Institut NeuroMyoGène</orgName>
          <orgName type="acronym">INMG</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment Gregor Mendel 16 Rue Raphel Dubois69622 Villeurbanne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inmg.fr/en/index.php</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="U1217" active="#struct-303623" type="direct"/>
            <relation name="UMR5310" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1079399" status="INCOMING">
          <orgName>Oncofactory SAS</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="department" xml:id="struct-1061087" status="VALID">
          <idno type="IdRef">260512567</idno>
          <idno type="ROR">https://ror.org/0557vhy43</idno>
          <orgName>BioSanté</orgName>
          <orgName type="acronym">UMR BioSanté</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>17 rue des Martyrs 38054 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosante-lab.fr/Pages/Presentation.aspx</ref>
          </desc>
          <listRelation>
            <relation name="UMR 1292" active="#struct-303623" type="direct"/>
            <relation name="DRF/IRIG/DS" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-106195" status="VALID">
          <idno type="IdRef">157042456</idno>
          <idno type="RNSR">201019092N</idno>
          <idno type="ROR">03mxktp47</idno>
          <orgName>Institut de biologie de l'ENS Paris</orgName>
          <orgName type="acronym">IBENS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>46, Rue d’Ulm75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ibens.bio.ens.psl.eu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-34292" type="direct"/>
            <relation active="#struct-59704" type="indirect"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
            <relation name="U1024" active="#struct-303623" type="direct"/>
            <relation name="UMR8197" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-20549" status="VALID">
          <idno type="ROR">https://ror.org/01cmnjq37</idno>
          <orgName>Centre Léon Bérard [Lyon]</orgName>
          <desc>
            <address>
              <addrLine>28, rue Laennec 69373 LYON Cedex 08</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centreleonberard.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-348446" status="VALID">
          <idno type="ROR">https://ror.org/0075rng13</idno>
          <orgName>Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL]</orgName>
          <orgName type="acronym">IHOPe</orgName>
          <desc>
            <address>
              <addrLine>1 place Professeur Joseph Renault69008 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/institut-hematologie-et-oncologie-pediatrique-ihope</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-34292" status="VALID">
          <orgName>Département de Biologie - ENS-PSL</orgName>
          <orgName type="acronym">IBENS</orgName>
          <date type="start">1987-01-01</date>
          <desc>
            <address>
              <addrLine>Département de BiologieENS Ulm46 rue d 'Ulm75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.biologie.ens.fr/depbio/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-59704" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-59704" status="VALID">
          <idno type="IdRef">031738419</idno>
          <idno type="ISNI">0000000123532622</idno>
          <idno type="ROR">https://ror.org/05a0dhs15</idno>
          <orgName>École normale supérieure - Paris</orgName>
          <orgName type="acronym">ENS-PSL</orgName>
          <date type="start">1985-07-24</date>
          <desc>
            <address>
              <addrLine>45, Rue d'Ulm - 75230 Paris cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ens.psl.eu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50259" status="VALID">
          <idno type="anr">ANR-17-EURE-0003</idno>
          <orgName>CBH-EUR-GS</orgName>
          <desc>CBH-EUR-GS</desc>
          <date type="start">2017</date>
        </org>
        <org type="anrProject" xml:id="projanr-49741" status="VALID">
          <idno type="anr">ANR-10-LABX-0061</idno>
          <orgName>DEVWECAN</orgName>
          <desc>Development Cancer and Targeted Therapies</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>