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            <title xml:lang="en">Mediation of Interleukin‐23 and Tumor Necrosis Factor–Driven Reactive Arthritis by Chlamydia ‐Infected Macrophages in SKG Mice</title>
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                <forename type="first">Xavier</forename>
                <surname>Romand</surname>
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                <forename type="first">Xiao</forename>
                <surname>Liu</surname>
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              <idno type="halauthorid">780356-0</idno>
              <affiliation ref="#struct-250752"/>
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              <persName>
                <forename type="first">M. Arifur</forename>
                <surname>Rahman</surname>
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              <affiliation ref="#struct-250752"/>
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                <forename type="first">Zaied Ahmed</forename>
                <surname>Bhuyan</surname>
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              <affiliation ref="#struct-250752"/>
              <affiliation ref="#struct-473375"/>
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                <forename type="first">Reena Arora</forename>
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              <affiliation ref="#struct-250752"/>
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                <forename type="first">Dominique</forename>
                <surname>Roest</surname>
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              <affiliation ref="#struct-250752"/>
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              <persName>
                <forename type="first">Zi Huai</forename>
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                <forename type="first">Amy</forename>
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                <forename type="first">Linda</forename>
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                <forename type="first">Aurélie</forename>
                <surname>Bozon</surname>
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            <author role="aut">
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                <forename type="first">Mohammed</forename>
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                <forename type="first">Charles</forename>
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                <forename type="first">Minh Vu Chuong</forename>
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              <date type="whenModified">2025-11-24 16:02:03</date>
              <date type="whenReleased">2024-12-09 22:45:19</date>
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            <idno type="halRefHtml">&lt;i&gt;Arthritis &amp; rheumatology&lt;/i&gt;, 2021, 73 (7), pp.1200-1210. &lt;a target="_blank" href="https://dx.doi.org/10.1002/art.41653"&gt;&amp;#x27E8;10.1002/art.41653&amp;#x27E9;&lt;/a&gt;</idno>
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            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
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            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="TIMC-TREE" corresp="TIMC-IMAG">TrEE : Translational microbial Evolution and Engineering</idno>
            <idno type="stamp" n="TIMC-GREPI" corresp="TIMC-IMAG">T-RAIG : Translationnal Research in Autoimmunity and Inflammation Group</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
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            <note type="popular" n="0">No</note>
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                <title xml:lang="en">Mediation of Interleukin‐23 and Tumor Necrosis Factor–Driven Reactive Arthritis by Chlamydia ‐Infected Macrophages in SKG Mice</title>
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                    <forename type="first">Reena Arora</forename>
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                    <surname>Bozon</surname>
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                    <forename type="first">Mohammed</forename>
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                    <forename type="first">Minh Vu Chuong</forename>
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                    <forename type="first">Philippe</forename>
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                <idno type="issn">2326-5205</idno>
                <idno type="eissn">2326-5191</idno>
                <title level="j">Arthritis &amp; rheumatology</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">73</biblScope>
                  <biblScope unit="issue">7</biblScope>
                  <biblScope unit="pp">1200-1210</biblScope>
                  <date type="datePub">2021-07</date>
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              <idno type="doi">10.1002/art.41653</idno>
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              <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
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            <abstract xml:lang="en">
              <p>Pseudomonas aeruginosa (P.a) is one of the most critical antibiotic resistant bacteria in the world and is the most prevalent pathogen in cystic fibrosis (CF), causing chronic lung infections that are considered one of the major causes of mortality in CF patients. Although several studies have contributed to understanding P.a within-host adaptive evolution at a genomic level, it is still difficult to establish direct relationships between the observed mutations, expression of clinically relevant phenotypes, and clinical outcomes. Here, we performed a comparative untargeted LC/HRMS-based metabolomics analysis of sequential isolates from chronically infected CF patients to obtain a functional view of P.a adaptation. Metabolic profiles were integrated with expression of bacterial phenotypes and clinical measurements following multiscale analysis methods. Our results highlighted significant associations between P.a “metabotypes”, expression of antibiotic resistance and virulence phenotypes, and frequency of clinical exacerbations, thus identifying promising biomarkers and therapeutic targets for difficult-to-treat P.a infections</p>
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