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Article Dans Une Revue Journal of flow chemistry Année : 2022

A multi-step continuous flow synthesis of pomalidomide

Résumé

The immunomodulatory drugs (IMiDs) thalidomide, pomalidomide, and lenalidomide are widely used to treat multiple myeloma. The permanent need of IMiDs analogues in clinical screening and practice has created the demand to find a reliable and robust method for their preparation. To reach this goal, the use of flow chemistry is quite appealing, allowing a safe operation, an excellent reproducibility and an efficient process.

Domaines

Chimie
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Dates et versions

hal-03838950 , version 1 (03-11-2022)

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Maria Ivanova, Julien Legros, Thomas Poisson, Philippe Jubault. A multi-step continuous flow synthesis of pomalidomide. Journal of flow chemistry, 2022, 12, pp.383-387. ⟨10.1007/s41981-022-00223-3⟩. ⟨hal-03838950⟩
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