The physical properties of 149,152,155,161 Tb enable their use in both diagnostic and therapeutic applications in the field of nuclear medicine. For this reason the optimization of the production routes of these radionuclides is of widespread interest in research. In this work, the feasibility of the production of 155 Tb and 161 Tb via the nuclear reactions induced by deuterons on dysprosium target with natural isotopic abundances has been discussed. The cross sections of nat Dy(d,x) reactions have been studied in the 12.5–32 MeV energetic range with the stacked-foil technique and the corresponding Thick Target Yields have been obtained. The presence of terbium and dysprosium contaminants (156,160 Tb, 155,157,159 Dy) has been evaluated too.