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                <title level="j">Rheumatology</title>
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                <term xml:lang="en">systemic sclerosis</term>
                <term xml:lang="en">scleroderma</term>
                <term xml:lang="en">lung fibrosis</term>
                <term xml:lang="en">autoantibodies</term>
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              <p>OBJECTIVES: The prevalence and characteristics of systemic sclerosis-associated interstitial lung disease (SSc-ILD) vary between geographical regions worldwide. The objectives of this study were to explore the differences in terms of prevalence, phenotype, treatment, and prognosis in patients with SSc-ILD from predetermined geographical regions in the EUSTAR database. METHODS: Patients were clustered into seven geographical regions. Clinical characteristics and survival of patients with SSc-ILD were compared among these pre-determined regions. RESULTS: For baseline analyses, 9260 SSc patients were included, with 6732 for survival analyses. The prevalence of SSc-ILD in the overall population was 50.2%, ranging from 44.0% in &amp;quot;Western Europe and Nordic countries&amp;quot; to 67.5% in &amp;quot;Eastern European, Russia and Baltic countries&amp;quot;. In all regions, anti-topoisomerase antibodies were associated with SSc-ILD. Management also significantly differed; mycophenolate mofetil was prescribed at baseline in 31.6% of patients with SSc-ILD in &amp;quot;America (North and South)&amp;quot; and 31.7% in &amp;quot;Middle East&amp;quot; but only 4.3% in &amp;quot;Asia and Oceania&amp;quot; (P &amp;lt; 0.0001). Patients from &amp;quot;America (North and South)&amp;quot; and &amp;quot;Middle East&amp;quot; had the highest survival rate at the end of follow-up (85.8% and 85.2%, respectively). CONCLUSION: Our study highlights key differences among regions in terms of clinical presentation and prognosis of SSc-ILD. This work also demonstrates that the management of SSc-ILD is highly variable among the different regions considered, suggesting that efforts are still needed for the standardisation of medical practice in the treatment of this disease.</p>
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            <address>
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            <address>
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          <orgName type="acronym">CNRS</orgName>
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