Journal Articles Small Year : 2022

Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging

Susana Carregal-Romero
Ana Beatriz Miguel-Coello
  • Function : Author
Lydia Martínez-Parra
  • Function : Author
Yolanda Martí-Mateo
  • Function : Author
Pablo Hernansanz-Agustín
  • Function : Author
Yilian Fernández-Afonso
  • Function : Author
Sandra Plaza-García
  • Function : Author
Lucía Gutiérrez
  • Function : Author
Juliana Carrillo-Romero
  • Function : Author
Marina Piñol-Cancer
  • Function : Author
Pierre Lecante
Zuriñe Blasco-Iturri
  • Function : Author
Lucía Fadón
  • Function : Author
Ana Almansa-García
  • Function : Author
Marco Möller
  • Function : Author
Dorleta Otaegui
  • Function : Author
Jose Antonio Enríquez
  • Function : Author
Jesús Ruíz-Cabello
  • Function : Author

Abstract

Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost-efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (MnxFe3-xO4, 0.1 ≤ x ≤ 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual-mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase-mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications.

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hal-03836427 , version 1 (02-11-2022)

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Susana Carregal-Romero, Ana Beatriz Miguel-Coello, Lydia Martínez-Parra, Yolanda Martí-Mateo, Pablo Hernansanz-Agustín, et al.. Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging. Small, 2022, 18 (16), pp.2106570. ⟨10.1002/smll.202106570⟩. ⟨hal-03836427⟩
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