Synthesis and characterization of new 1,3,4-thiadiazole derivatives: study of their antibacterial activity and CT-DNA binding - Archive ouverte HAL Access content directly
Journal Articles RSC Advances Year : 2022

Synthesis and characterization of new 1,3,4-thiadiazole derivatives: study of their antibacterial activity and CT-DNA binding

Hakan Sayiner
  • Function : Author
Mehmet Yilmazer
Aisha. Abdelsalam
  • Function : Author
Mohamed Ganim
  • Function : Author
Cengiz Baloglu
  • Function : Author
Yasemin Celik Altunoglu
  • Function : Author
Mahmut Gür
Mohamed Attia
Safwat Mahmoud
  • Function : Author
Ekram Mohamed
Nora Hamad Al-Shaalan
Sarah Alharthi
Fatma Kandemirli
  • Function : Correspondent author
  • PersonId : 1180536

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Mohammed Amin

Abstract

1,3,4-Thiadiazole molecules (1–4) were synthesized by the reaction of phenylthiosemicarbazide and methoxy cinnamic acid molecules in the presence of phosphorus oxychloride, and characterized with UV, FT-IR, 13C-NMR, and 1H-NMR methods. DFT calculations (b3lyp/6-311++G(d,p)) were performed to investigate the structures' geometry and physiochemical properties. Their antibacterial activity was screened for various bacteria strains such as Enterobacter aerogenes, Escherichia coli ATCC 13048, Salmonella kentucky, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus and Gram positive such as Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 7644, Enterococcus faecium, Enterococcus durans, Staphylococcus aureus ATCC, Serratia marcescens, Staphylococcus hominis, Staphylococcus epidermidis, alfa Streptococcus haemolyticus, Enterococcus faecium and found to have an inhibitory effect on Klebsiella pneumoniae and Staphylococcus hominis, while molecules 1, 3 and 4 had an inhibitory effect on Staphylococcus epidermidis and alpha Streptococcus haemolyticus. The experimental results were supported by the docking study using the Kinase ThiM from Klebsiella pneumoniae. All the investigated compounds showed an inhibitory effect for the Staphylococcus epidermidis protein. In addition, the mechanism of the 1–4 molecule interaction with calf thymus-DNA (CT-DNA) was investigated by UV-vis spectroscopic methods.
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Dates and versions

hal-03835355 , version 1 (31-10-2022)

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Attribution - NonCommercial

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Hakan Sayiner, Mehmet Yilmazer, Aisha. Abdelsalam, Mohamed Ganim, Cengiz Baloglu, et al.. Synthesis and characterization of new 1,3,4-thiadiazole derivatives: study of their antibacterial activity and CT-DNA binding. RSC Advances, 2022, 12 (46), pp.29627-29639. ⟨10.1039/D2RA02435G⟩. ⟨hal-03835355⟩
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