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Journal Articles Nature Year : 1995

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Ja-Hyun Baik
  • Function : Author
Roberto Picetti
  • Function : Author
Adolfo Saiardi
  • Function : Author
Graziella Thiriet
  • Function : Author
Antoine Depaulis
  • Function : Author
Marianne Le Meur
  • Function : Author
Emiliana Borrelli
  • Function : Author

Abstract

Dopaminergic neuronal pathways arise from mesencephalic nuclei and project axons to the striatum, cortex, limbic system and hypothalamus. Through these pathways dopamine affects many physiological functions, such as the control of coordinated movement and hormone secretion. Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice. Absence of D2 receptors leads to animals that are akinetic and bradykinetic in behavioural tests, and which show significantly reduced spontaneous movements. This phenotype presents analogies with symptoms characteristic of Parkinson's disease. Our study shows that D2 receptors have a key role in the dopaminergic control of nervous function. These mice have therapeutic potential as a model for investigating and correcting dysfunctions of the dopaminergic system.

Dates and versions

hal-03832793 , version 1 (27-10-2022)

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Ja-Hyun Baik, Roberto Picetti, Adolfo Saiardi, Graziella Thiriet, Andrée Dierich, et al.. Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature, 1995, 377 (6548), pp.424-428. ⟨10.1038/377424a0⟩. ⟨hal-03832793⟩
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