Article Dans Une Revue Acta Biomaterialia Année : 2022

Biomaterial functionalization with triple-helical peptides for tissue engineering

Résumé

In the growing field of tissue engineering, providing cells in biomaterials with the adequate biological cues represents an increasingly important challenge. Yet, biomaterials with excellent mechanical properties are often biologically inert to many cell types. To address this issue, researchers resort to functionalization, i.e. the surface modification of a biomaterial with active molecules or substances. Functionalization notably aims to replicate the native cellular microenvironment provided by the extracellular matrix, and in particular by collagen, its major component. As our understanding of biological processes regulating cell behavior increases, functionalization with biomolecules binding cell surface receptors constitutes a promising strategy. Among these, triple-helical peptides (THPs) that reproduce the architectural and biological properties of collagen are especially attractive. Indeed, THPs containing binding sites from the native collagen sequence have successfully been used to guide cell response by establishing cell-biomaterial interactions. Notably, the GFOGER motif recognizing the collagen-binding integrins is extensively employed as a cell adhesive peptide. In biomaterials, THPs efficiently improved cell adhesion, differentiation and function on biomaterials designed for tissue repair (especially for bone, cartilage and heart), vascular graft fabrication, wound dressing, drug delivery or immunomodulation. This review describes the key characteristics of THPs, their effect on cells when combined to biomaterials and their strong potential as biomimetic tools for regenerative medicine.

Fichier principal
Vignette du fichier
Acta Biomaterialia (1).pdf (4.7 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-03823988 , version 1 (27-10-2022)

Licence

Identifiants

Citer

Jean-Daniel Malcor, Frédéric Mallein-Gerin. Biomaterial functionalization with triple-helical peptides for tissue engineering. Acta Biomaterialia, 2022, 148, pp.1-21. ⟨10.1016/j.actbio.2022.06.003⟩. ⟨hal-03823988⟩
112 Consultations
643 Téléchargements

Altmetric

Partager

  • More