Combined ultrasound and light backscattering spectroscopy for cancer characterization: a proof of concept - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2022

Combined ultrasound and light backscattering spectroscopy for cancer characterization: a proof of concept

Cyril Malinet
Herve Liebgott
Pauline Muleki-Seya

Résumé

Changes in the tissue microstructure occur at the cellular and nuclear scales when a tissue turns malignant. With the aim of assessing these alterations in a quantitative fashion, an ultrasound and a light backscattering technique have been combined to extract the scatterer size distribution from three different tissue-mimicking phantoms (diameter of 10 µm, 20 µm and 60 µm). The light-based technique showed more potential to characterize the 60 µm phantom (agreement with expected model R² = 0.94) than the ultrasound-based method, which in turn better models and discriminates the 10 µm and the 20 µm phantom (R² = 0.93 and R² = 0.84 respectively). Results suggest that the two modalities could have complementary sensitivities regarding the scatterer sizes. The bimodal technique could potentially probe tumor microstructures at various scales, thereby allowing a thorough tissue characterization.
Fichier non déposé

Dates et versions

hal-03819352 , version 1 (18-10-2022)

Identifiants

  • HAL Id : hal-03819352 , version 1

Citer

Cyril Malinet, Bruno Montcel, Aurélie Dutour, Herve Liebgott, Pauline Muleki-Seya. Combined ultrasound and light backscattering spectroscopy for cancer characterization: a proof of concept. 2022 IEE IUS, Oct 2022, Venise, Italy. ⟨hal-03819352⟩
45 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More