<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03819115</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T05:02:09+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties</title>
            <author role="aut">
              <persName>
                <forename type="first">Estelle</forename>
                <surname>Palierse</surname>
              </persName>
              <idno type="idhal" notation="numeric">802622</idno>
              <idno type="halauthorid" notation="string">2016125-802622</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2643-5347</idno>
              <idno type="IDREF">https://www.idref.fr/251640337</idno>
              <affiliation ref="#struct-542012"/>
              <affiliation ref="#struct-541749"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Masse</surname>
              </persName>
              <idno type="halauthorid">34904-0</idno>
              <affiliation ref="#struct-542012"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Laurent</surname>
              </persName>
              <email type="md5">8f9bd93c41f0c2dea9d3bf69bc7233ea</email>
              <email type="domain">sorbonne-universite.fr</email>
              <idno type="idhal" notation="string">guillaume-laurent-cmcp</idno>
              <idno type="idhal" notation="numeric">13622</idno>
              <idno type="halauthorid" notation="string">45222-13622</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-4328-2012</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8127-5326</idno>
              <idno type="IDREF">https://www.idref.fr/257319336</idno>
              <affiliation ref="#struct-542013"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Le Griel</surname>
              </persName>
              <idno type="halauthorid">998647-0</idno>
              <affiliation ref="#struct-542010"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gervaise</forename>
                <surname>Mosser</surname>
              </persName>
              <idno type="halauthorid">1843-0</idno>
              <affiliation ref="#struct-542012"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thibaud</forename>
                <surname>Coradin</surname>
              </persName>
              <email type="md5">297a8897ddda874671802c843274144e</email>
              <email type="domain">upmc.fr</email>
              <idno type="idhal" notation="string">thibaud-coradin</idno>
              <idno type="idhal" notation="numeric">12986</idno>
              <idno type="halauthorid" notation="string">1008761-12986</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3374-5722</idno>
              <idno type="IDREF">https://www.idref.fr/149882912</idno>
              <idno type="VIAF">https://viaf.org/viaf/282276076</idno>
              <idno type="ISNI">http://isni.org/isni/0000000388955209</idno>
              <affiliation ref="#struct-542012"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claude</forename>
                <surname>Jolivalt</surname>
              </persName>
              <email type="md5">cc7e2842206dd93c860d28fe8a566931</email>
              <email type="domain">sorbonne-universite.fr</email>
              <idno type="idhal" notation="numeric">1175871</idno>
              <idno type="halauthorid" notation="string">541152-1175871</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0318-5421</idno>
              <idno type="IDREF">https://www.idref.fr/144566923</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CYI-4330-2022</idno>
              <idno type="VIAF">https://viaf.org/viaf/205033450</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CYI-4330-2022</idno>
              <affiliation ref="#struct-541749"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Thibaud</forename>
                <surname>Coradin</surname>
              </persName>
              <email type="md5">297a8897ddda874671802c843274144e</email>
              <email type="domain">upmc.fr</email>
            </editor>
            <funder ref="#projanr-49746"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-10-18 11:49:55</date>
              <date type="whenWritten">2022-09-12</date>
              <date type="whenModified">2025-06-21 03:24:11</date>
              <date type="whenReleased">2022-12-19 14:30:43</date>
              <date type="whenProduced">2022</date>
              <date type="whenEndEmbargoed">2022-10-18</date>
              <ref type="file" target="https://hal.science/hal-03819115v1/document">
                <date notBefore="2022-10-18"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-03819115v1/file/Nanomaterials-12-03588.pdf" id="file-3905684-3414820">
                <date notBefore="2022-10-18"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.science/hal-03819115v1/file/nanomaterials-1938402-supplementary.pdf" id="file-3905684-3414821">
                <date notBefore="2022-12-18"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="338239">
                <persName>
                  <forename>Thibaud</forename>
                  <surname>Coradin</surname>
                </persName>
                <email type="md5">297a8897ddda874671802c843274144e</email>
                <email type="domain">upmc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03819115</idno>
            <idno type="halUri">https://hal.science/hal-03819115</idno>
            <idno type="halBibtex">palierse:hal-03819115</idno>
            <idno type="halRefHtml">&lt;i&gt;Nanomaterials&lt;/i&gt;, 2022, 12 (20), pp.3588. &lt;a target="_blank" href="https://dx.doi.org/10.3390/nano12203588"&gt;&amp;#x27E8;10.3390/nano12203588&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nanomaterials, 2022, 12 (20), pp.3588. &amp;#x27E8;10.3390/nano12203588&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3905684-3414820"/><ref corresp="#file-3905684-3414821"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="LRS" corresp="SORBONNE-UNIVERSITE">Laboratoire de Réactivité de Surface</idno>
            <idno type="stamp" n="LCMCP" corresp="SORBONNE-UNIVERSITE">Laboratoire de Chimie de la Matière Condensée de Paris</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="LCMCP-SMILES" corresp="LCMCP">Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé</idno>
            <idno type="stamp" n="LCMCP-MATBIO" corresp="LCMCP">Matériaux et Biolologie</idno>
            <idno type="stamp" n="MATISSE" corresp="SORBONNE-UNIVERSITE">Labex MATISSE</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="CHIMIE-SU" corresp="SORBONNE-UNIVERSITE">UFR de Chimie de Sorbonne-Université</idno>
            <idno type="stamp" n="SUPRA_PHYS_CHIMIE">Physico-Chimie</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Synthesis of Hybrid Polyphenol/Hydroxyapatite Nanomaterials with Anti-Radical Properties</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Estelle</forename>
                    <surname>Palierse</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">802622</idno>
                  <idno type="halauthorid" notation="string">2016125-802622</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2643-5347</idno>
                  <idno type="IDREF">https://www.idref.fr/251640337</idno>
                  <affiliation ref="#struct-542012"/>
                  <affiliation ref="#struct-541749"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Masse</surname>
                  </persName>
                  <idno type="halauthorid">34904-0</idno>
                  <affiliation ref="#struct-542012"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Laurent</surname>
                  </persName>
                  <email type="md5">8f9bd93c41f0c2dea9d3bf69bc7233ea</email>
                  <email type="domain">sorbonne-universite.fr</email>
                  <idno type="idhal" notation="string">guillaume-laurent-cmcp</idno>
                  <idno type="idhal" notation="numeric">13622</idno>
                  <idno type="halauthorid" notation="string">45222-13622</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-4328-2012</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8127-5326</idno>
                  <idno type="IDREF">https://www.idref.fr/257319336</idno>
                  <affiliation ref="#struct-542013"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Le Griel</surname>
                  </persName>
                  <idno type="halauthorid">998647-0</idno>
                  <affiliation ref="#struct-542010"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gervaise</forename>
                    <surname>Mosser</surname>
                  </persName>
                  <idno type="halauthorid">1843-0</idno>
                  <affiliation ref="#struct-542012"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thibaud</forename>
                    <surname>Coradin</surname>
                  </persName>
                  <email type="md5">297a8897ddda874671802c843274144e</email>
                  <email type="domain">upmc.fr</email>
                  <idno type="idhal" notation="string">thibaud-coradin</idno>
                  <idno type="idhal" notation="numeric">12986</idno>
                  <idno type="halauthorid" notation="string">1008761-12986</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3374-5722</idno>
                  <idno type="IDREF">https://www.idref.fr/149882912</idno>
                  <idno type="VIAF">https://viaf.org/viaf/282276076</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000388955209</idno>
                  <affiliation ref="#struct-542012"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claude</forename>
                    <surname>Jolivalt</surname>
                  </persName>
                  <email type="md5">cc7e2842206dd93c860d28fe8a566931</email>
                  <email type="domain">sorbonne-universite.fr</email>
                  <idno type="idhal" notation="numeric">1175871</idno>
                  <idno type="halauthorid" notation="string">541152-1175871</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0318-5421</idno>
                  <idno type="IDREF">https://www.idref.fr/144566923</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CYI-4330-2022</idno>
                  <idno type="VIAF">https://viaf.org/viaf/205033450</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CYI-4330-2022</idno>
                  <affiliation ref="#struct-541749"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">102666</idno>
                <idno type="issn">2079-4991</idno>
                <idno type="eissn">2079-4991</idno>
                <title level="j">Nanomaterials</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">12</biblScope>
                  <biblScope unit="issue">20</biblScope>
                  <biblScope unit="pp">3588</biblScope>
                  <date type="datePub">2022</date>
                  <date type="dateEpub">2022-10-13</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/nano12203588</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">crystal growth</term>
                <term xml:lang="en">polyphenol</term>
                <term xml:lang="en">hydroxyapatite</term>
              </keywords>
              <classCode scheme="halDomain" n="chim.mate">Chemical Sciences/Material chemistry</classCode>
              <classCode scheme="halDomain" n="chim.ther">Chemical Sciences/Medicinal Chemistry</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Plant-derived natural bioactive molecules are of great therapeutic potential but, so far, their application in nanomedicine has scarcely been studied. This work aimed at comparing two methodologies, i.e., adsorption and in situ incorporation, to prepare hybrid polyphenol/hydroxyapatite nanoparticles. Two flavonoids, baicalin and its aglycone derivative baicalein, and two phenolic acids derived from caffeic acid, rosmarinic and chlorogenic acids, were studied. Adsorption of these polyphenols on pre-formed hydroxyapatite nanoparticles did not modify particle size or shape and loading was less than 10% (w/w). In contrast, presence of polyphenols during the synthesis of nanoparticles significantly impacted and sometimes fully inhibited hydroxyapatite formation but recovered particles could exhibit higher loadings. For most hybrid particles, release profiles consisted of a 24 h burst effect followed by a slow release over 2 weeks. Antioxidant properties of the polyphenols were preserved after adsorption but not when incorporated in situ. These results provide fruitful clues for the valorization of natural bioactive molecules in nanomedicine.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-542012" status="VALID">
          <orgName>Matériaux et Biologie</orgName>
          <orgName type="acronym">LCMCP-MATBIO</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-542010" type="direct"/>
            <relation active="#struct-341038" type="indirect"/>
            <relation active="#struct-413221" type="indirect"/>
            <relation name="UMR7574" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-541749" status="VALID">
          <idno type="IdRef">241292727</idno>
          <idno type="ISNI">0000000403699793</idno>
          <idno type="RNSR">200919198H</idno>
          <idno type="ROR">https://ror.org/04vthwx70</idno>
          <orgName>Laboratoire de Réactivité de Surface</orgName>
          <orgName type="acronym">LRS</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Tour 54- 2ème etg 4 Place Jussieu - Case 178 75252 PARIS CEDEX 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lrs.sorbonne-universite.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-341038" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR7197" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-542013" status="VALID">
          <orgName>Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé</orgName>
          <orgName type="acronym">LCMCP-SMiLES</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-542010" type="direct"/>
            <relation active="#struct-341038" type="indirect"/>
            <relation active="#struct-413221" type="indirect"/>
            <relation name="UMR7574" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-542010" status="VALID">
          <idno type="IdRef">240311051</idno>
          <idno type="ISNI">0000 0004 0369 7931</idno>
          <idno type="RNSR">199712620K</idno>
          <idno type="ROR">https://ror.org/028ta1f94</idno>
          <orgName>Laboratoire de Chimie de la Matière Condensée de Paris</orgName>
          <orgName type="acronym">LCMCP</orgName>
          <date type="start">2014-01-01</date>
          <desc>
            <address>
              <addrLine>Sorbonne Université4 place Jussieu75252 Paris cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.labos.upmc.fr/lcmcp</ref>
          </desc>
          <listRelation>
            <relation active="#struct-341038" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR7574" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-49746" status="VALID">
          <idno type="anr">ANR-10-LABX-0067</idno>
          <orgName>MATISSE</orgName>
          <desc>MATerials, InterfaceS, Surfaces, Environment</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>