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Article Dans Une Revue Cellular and Molecular Biology Année : 1991

Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status

Jean-Noël Freund
C. Foltzer-Jourdainne
  • Fonction : Auteur
Isabelle Duluc
  • Fonction : Auteur
  • PersonId : 1119751
M. Galluser
  • Fonction : Auteur
F. Gosse
  • Fonction : Auteur
Francis Raul
  • Fonction : Auteur
  • PersonId : 1065546

Résumé

The effect of glucocorticoids and thyroid hormones on lactase expression was investigated along the small intestine of rats. In sucklings thyroxine injections promoted a precocious drop of enzyme activity but not of mRNA. Hydrocortisone did neither modify lactase activity nor its mRNA expression. In adults decreasing the amount of thyroid hormones led to a slight and reversible increase of the lactase mRNA content whereas lactase activity rised more dramatically. Thus, thyroid hormones in contrast to corticoids, are involved in the posttranscriptional control of lactase during the suckling period. Yet, none of these hormones might induced the modification of the longitudinal distribution of the lactase mRNA that occurred at weaning.

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Autre [q-bio.OT]
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Dates et versions

hal-03818491 , version 1 (17-10-2022)

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  • HAL Id : hal-03818491 , version 1

Citer

Jean-Noël Freund, C. Foltzer-Jourdainne, Isabelle Duluc, M. Galluser, F. Gosse, et al.. Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status. Cellular and Molecular Biology, 1991, 37 (4), pp.463-466. ⟨hal-03818491⟩

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