Article Dans Une Revue The Plant cell Année : 2009

Two Types of Meiotic Crossovers Coexist in Maize

Résumé

Abstract We apply modeling approaches to investigate the distribution of late recombination nodules in maize (Zea mays). Such nodules indicate crossover positions along the synaptonemal complex. High-quality nodule data were analyzed using two different interference models: the “statistical” gamma model and the “mechanical” beam film model. For each chromosome, we exclude at a 98% significance level the hypothesis that a single pathway underlies the formation of all crossovers, pointing to the coexistence of two types of crossing-over in maize, as was previously demonstrated in other organisms. We estimate the proportion of crossovers coming from the noninterfering pathway to range from 6 to 23% depending on the chromosome, with a cell average of ∼15%. The mean number of noninterfering crossovers per chromosome is significantly correlated with the length of the synaptonemal complex. We also quantify the intensity of interference. Finally, we develop inference tools that allow one to tackle, without much loss of power, complex crossover interference models such as the beam film. The lack of a likelihood function in such models had prevented their use for parameter estimation. This advance will allow more realistic mechanisms of crossover formation to be modeled in the future.

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Dates et versions

hal-03818408 , version 1 (17-10-2022)

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Matthieu Falque, Lorinda Anderson, Stephen Stack, Franck Gauthier, Olivier Martin. Two Types of Meiotic Crossovers Coexist in Maize. The Plant cell, 2009, 21 (12), pp.3915-3925. ⟨10.1105/tpc.109.071514⟩. ⟨hal-03818408⟩
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