We identify the source of the Mw = 5.6 earthquake that hit west-central Epirus on 21 March 2020 00:49:52 UTC. We use Sentinel-1 synthetic aperture radar interferograms tied to one permanent Global Navigation Satellite System (GNSS) station (GARD). We model the source by inverting the INSAR displacement data. The inversion model suggests a shallow source on a low-angle fault (39°) dipping towards east with a centroid depth of 8.5 km. The seismic moment deduced from our model agrees with those of the published seismic moment tensors. This geometry is compatible with reverse-slip motion along the west-verging Margariti thrust fault that accommodates part of the convergence within the collision zone between Apulia and Eurasia. We also processed new GNSS data and estimate a total convergence rate between Apulia and Eurasia of 8.9 mm yr−1, of which the shortening of the crust between the Epirus coastal GNSS stations and station PAXO in the Ionian Sea (across the Ionian Thrust) is equivalent to ~50% of it or 4.6 mm yr−1. By back-slip modelling we found that a 60-km wide deformation zone takes up nearly most of the convergence between Apulia-Eurasia, trending N318°E. Its central axis runs along the southwest coast of Corfu, along the northeast coast of Paxoi, heading toward the northern extremity of the Lefkada island. The island of Paxoi appears kinematically as part of the Apulian plate.