White light spectroscopy for T-cell culture growth monitoring: towards a real-time and sampling free device for ATMPs production
Résumé
Nowadays, Advanced Therapy Medicinal Products (ATMPs) are new generation of pharmaceuticals which offer novel and revolutionary answer to be given to patients at the end of their therapeutic options. However, because of their prohibitive cost, they can only be proposed to a reduced number of patients. One possibility to reduce ATMP’ price is to automate their production as much as possible. Among the numerous possibilities, a real-time and closed loop monitoring of the T-cell growth during the expansion phase would be appreciated. In this short paper, we propose a simple white light spectroscopy method which can be easily implemented in such an autonomous device and able to monitor T-cell number evolution with a higher accuracy as compared to current cell counting methods.
Origine : Fichiers éditeurs autorisés sur une archive ouverte